Novel subcellular distribution pattern of A-type K+ channels on neuronal surface

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Mihaly KolloZoltan Nusser

Abstract

Potassium channels comprise the most diverse family of ion channels. In nerve cells, their critical roles in synaptic integration and output generation have been demonstrated. Here, we provide evidence for a distribution that predicts a novel role of K+ channels in the CNS. Our experiments revealed a highly selective clustering of the Kv4.3 A-type K+ channel subunits at specialized junctions between climbing fibers and cerebellar GABAergic interneurons. High-resolution ultrastructural and immunohistochemical experiments demonstrated that these junctions are distinct from known chemical and electrical (gap junctions) synapses and also from puncta adherentia. Each cerebellar interneuron contains many such K+ channel-rich specializations, which seem to be distributed throughout the somatodendritic surface. We also show that such K+ channel-rich specializations are not only present in the cerebellum but are widespread in the rat CNS. For example, mitral cells of the main olfactory bulb establish Kv4.2 subunit-positive specializations with each other. At these specializations, both apposing membranes have a high density of K+ channels, indicating bidirectional signaling. Similar specializations with pronounced coclustering of the Kv...Continue Reading

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Citations

May 26, 2007·Nature Neuroscience·Hiroshi Nishiyama, David J Linden
Feb 8, 2008·Neural Computation·Claude Meunier, Boris Lamotte d'Incamps
Mar 3, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Neal H Barmack, Vadim Yakhnitsa
Dec 15, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paul J MathewsThomas S Otis
Jan 2, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrea Lorincz, Zoltan Nusser
Mar 5, 2014·The Cerebellum·Luke T CoddingtonJacques I Wadiche
Sep 29, 2011·Neuroscience Letters·Zs SzabóI Sziklai
Mar 29, 2008·The European Journal of Neuroscience·Mihaly KolloZoltan Nusser
Mar 28, 2008·The European Journal of Neuroscience·Jamie JohnstonIan D Forsythe
Jan 3, 2013·Annals of Neurology·Stefan-M Pulst, Thomas S Otis
Nov 11, 2011·Hippocampus·Carmen Ballesteros-MerinoRafael Luján
Jan 11, 2014·The European Journal of Neuroscience·Carmen Ballesteros-MerinoRafael Luján
Aug 13, 2011·Channels·Ray W TurnerGerald W Zamponi
Apr 11, 2009·Neuroscience·G Szapiro, B Barbour
Feb 16, 2010·Nature Neuroscience·Dustin AndersonRay W Turner
May 19, 2006·Journal of Neurophysiology·Jason A Luther, Susan J Birren
May 27, 2020·The Journal of Comparative Neurology·Hajime ShiotaniYoshimi Takai
Oct 12, 2021·Molecular and Cellular Biochemistry·Kiyohito MizutaniYoshimi Takai

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