Novel supercritical carbon dioxide impregnation technique for the production of amorphous solid drug dispersions: a comparison to hot melt extrusion

Molecular Pharmaceutics
Catherine PotterGavin P Andrews

Abstract

The formulation of BCS Class II drugs as amorphous solid dispersions has been shown to provide advantages with respect to improving the aqueous solubility of these compounds. While hot melt extrusion (HME) and spray drying (SD) are among the most common methods for the production of amorphous solid dispersions (ASDs), the high temperatures often required for HME can restrict the processing of thermally labile drugs, while the use of toxic organic solvents during SD can impact on end-product toxicity. In this study, we investigated the potential of supercritical fluid impregnation (SFI) using carbon dioxide as an alternative process for ASD production of a model poorly water-soluble drug, indomethacin (INM). In doing so, we produced ASDs without the use of organic solvents and at temperatures considerably lower than those required for HME. Previous studies have concentrated on the characterization of ASDs produced using HME or SFI but have not considered both processes together. Dispersions were manufactured using two different polymers, Soluplus and polyvinylpyrrolidone K15 using both SFI and HME and characterized for drug morphology, homogeneity, presence of drug-polymer interactions, glass transition temperature, amorphous st...Continue Reading

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Citations

Feb 7, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Justine ThiryBrigitte Evrard
Jan 31, 2016·Advanced Drug Delivery Reviews·Teófilo VasconcelosBruno Sarmento
Dec 27, 2015·Advanced Drug Delivery Reviews·Abhishek Singh, Guy Van den Mooter
May 12, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Anna KrupaFlorence Danède
May 12, 2016·The Journal of Pharmacy and Pharmacology·Mohammed ManiruzzamanDennis Douroumis
Apr 2, 2017·International Journal of Pharmaceutics·Joanna SzafraniecRenata Jachowicz
Apr 21, 2017·Drug Development and Industrial Pharmacy·Kathavarayan Thenmozhi, Young Je Yoo
May 20, 2017·Pharmaceutical Research·Khadijah EduengChristel A S Bergström
Oct 31, 2017·Drug Development and Industrial Pharmacy·Rujie YangTianhong Zhang
May 21, 2019·Experimental and Therapeutic Medicine·Wenquan ZhuBaiyu Jian

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