Novel Superparamagnetic Microdevices Based on Magnetized PLGA/PLA Microparticles Obtained by Supercritical Fluid Emulsion and Coating by Carboxybetaine-Functionalized Chitosan Allowing the Tuneable Release of Therapeutics

Journal of Pharmaceutical Sciences
Vincenzo CricchioG Della Porta

Abstract

When superparamagnetic nanoparticles (MAG) are loaded within microcarriers of thermosensitive and injectable biopolymers, "smart" microdevices are obtained: they respond to an external magnetic field through the release of any co-encapsulated molecules with a remote on-off control. Creating reliable and effective fabrication technologies for the production of these smart nano/microdevices remains a challenge. In this work, supercritical emulsion extraction technology is proposed for the fabrication of microcapsules with a core of poly-lactic-co-glycolic acid (PLGA) or polylactic acid (PLA) covered by carboxybetaine-functionalized chitosan (f-chi) and loaded with MAG (mean size of 6.5 ± 3.0 nm) and water-soluble fluorescein (Fluo). Fluo is co-encapsulated as a fluorescent marker for the release study. Microcarriers showed a mean size of 800 ± 60 nm with an encapsulation efficiency of up to 90%. The inversion of surface charge, after the f-chi coating, suggested the presence of a uniform functionalized surface available for further chemical linkage. The external chitosan layer had a thickness of 200 ± 50 nm. An excellent MAG dispersion was confirmed within the biopolymer matrix that was shown to be responsive to external magnetic...Continue Reading

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Citations

Sep 18, 2020·International Journal of Molecular Sciences·Maria Rita CiteroniBarbara Barboni
Oct 16, 2020·Progress in Biomaterials·Elena LagrecaRaffaele Vecchione
Jun 12, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Fátima Fernández-ÁlvarezJosé L Arias
Jul 10, 2019·Biomacromolecules·Jason L GuoAntonios G Mikos

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