Novel suspension cell-based vaccine production systems for Rift Valley fever virus-like particles

Journal of Virological Methods
R B MandellR Flick

Abstract

Rift Valley fever virus (RVFV) is an arthropod-borne pathogen that often results in severe morbidity and mortality in both humans and livestock. As its geographic range continues to expand, it presents a real threat to naïve populations around the world by accidental introduction (e.g., the result of increased travel) or intentional release (e.g., a bioterror event). While there is a clear need for a safe and efficacious vaccine against this emerging and re-emerging pathogen, no FDA-approved vaccine is currently available. This need was addressed by the establishment of novel mammalian and insect suspension cell line systems for the efficient production of RVF virus-like particle (VLP)-based vaccine candidates. A direct comparison of the production of RVF VLPs in these systems was performed. Optimization and characterization resulted in a production platform suitable for scale-up. Furthermore, RVF VLP-based vaccines were tested in a lethal challenge model and showed full protection, demonstrating that RVF VLPs present promising RVFV vaccine candidates.

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Citations

Oct 1, 2011·Journal of Virology·Jeroen KortekaasRob J M Moormann
Oct 18, 2014·Vector Borne and Zoonotic Diseases·Bonto FaburayJuergen A Richt
Mar 19, 2014·Vaccine·Diego FontanaClaudio Prieto
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Nov 30, 2018·Biotechnology Journal·Sandiswa MbewanaEdward P Rybicki
Mar 19, 2013·Zoonoses and Public Health·R KoukuntlaR Flick

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