Novel synergistic mechanism for sst2 somatostatin and TNFalpha receptors to induce apoptosis: crosstalk between NF-kappaB and JNK pathways

Cell Death and Differentiation
Julie Guillermet-GuibertCorinne Bousquet

Abstract

Somatostatin is a multifunctional hormone that modulates cell proliferation, differentiation and apoptosis. Mechanisms for somatostatin-induced apoptosis are at present mostly unsolved. Therefore, we investigated whether somatostatin receptor subtype 2 (sst2) induces apoptosis in the nontransformed murine fibroblastic NIH3T3 cells. Somatostatin receptor subtype 2 expression induced an executioner caspase-mediated apoptosis through a tyrosine phosphatase SHP-1 (Src homology domain phosphatase-1)-dependent stimulation of nuclear factor kappa B (NF-kappaB) activity and subsequent inhibition of the mitogen-activated protein kinase JNK. Tumor necrosis factor alpha (TNFalpha) stimulated both NF-kappaB and c-Jun NH2-terminal kinase (JNK) activities, which had opposite action on cell survival. Importantly, sst2 sensitized NIH3T3 cells to TNFalpha-induced apoptosis by (1) upregulating TNFalpha receptor protein expression, and sensitizing to TNFalpha-induced caspase-8 activation; (2) enhancing TNFalpha-mediated activation of NF-kappaB, resulting in JNK inhibition and subsequent executioner caspase activation and cell death. We have here unraveled a novel signaling mechanism for a G protein-coupled receptor, which directly triggers apopto...Continue Reading

References

Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·L BuscailA V Schally
Apr 15, 1996·The Journal of Clinical Investigation·I RaulyC Susini
Mar 14, 1997·The Journal of Biological Chemistry·N MargolinD J Livingston
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·S HunotE C Hirsch
Jun 24, 1998·Cellular Immunology·A R KhaledJ Schiffenbauer
Aug 26, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·P T Massa, C Wu
Dec 3, 1998·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·J S Thompson
Feb 13, 1999·The Journal of Biological Chemistry·X M SunG M Cohen
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·C J AuernhammerS Melmed
Oct 3, 1999·The Journal of Biological Chemistry·M ThangarajuC B Srikant
Apr 29, 2000·Nature·K M RyanK H Vousden
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·B L BennettD W Anderson
Mar 27, 2002·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Rosa TeijeiroVictor M Arce
Oct 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Diego FeroneLeo J Hofland
Nov 26, 2002·Journal of Neuroimmunology·D LattuadaO Marelli
Dec 20, 2002·Proceedings of the National Academy of Sciences of the United States of America·Julie GuillermetCorinne Bousquet
Jan 1, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Anning Lin
May 24, 2003·Journal of Hepatology·Ulrike BöerGerhard P Püschel
Jul 25, 2003·The Journal of Biological Chemistry·Hicham LahlouChristiane Susini
Oct 14, 2003·Biochemical Pharmacology·Upasna Gaur, Bharat B Aggarwal
Dec 5, 2003·Nature Reviews. Drug Discovery·Gisbert WeckbeckerChristian Bruns
Apr 14, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C BousquetC Susini
Oct 8, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bing-Chang ChenChien-Huang Lin

❮ Previous
Next ❯

Citations

Jan 11, 2014·Trends in Endocrinology and Metabolism : TEM·Mounira ChalabiCorinne Bousquet
Jul 23, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Aristo VojdaniGottfried Kellermann
Mar 4, 2010·Journal of Experimental & Clinical Cancer Research : CR·Marialuisa Appetecchia, Roberto Baldelli
Mar 12, 2013·International Journal of Peptides·Federica BarbieriTullio Florio
May 2, 2014·Journal of Molecular Endocrinology·Tamar Eigler, Anat Ben-Shlomo
Nov 26, 2015·Human Gene Therapy·Georges VassauxPierre Cordelier
Dec 29, 2012·Trends in Endocrinology and Metabolism : TEM·Mônica R GadelhaMárta Korbonits
Mar 25, 2008·Molecular and Cellular Endocrinology·Stéphane PyronnetChristiane Susini
Oct 5, 2007·Molecular and Cellular Endocrinology·Tullio Florio
Jul 16, 2010·Journal of Cellular and Molecular Medicine·Mehtap CakirAshley Grossman
Jul 15, 2015·Advances in Biological Regulation·Romain BaerJulie Guillermet-Guibert
Jun 9, 2009·Journal of Experimental & Clinical Cancer Research : CR·Céline KerrosStéphane Allouche
Nov 19, 2018·Annals of the Rheumatic Diseases·Janine SchnieringBritta Maurer
Feb 3, 2011·World Journal of Surgery·Courtney J BalentineF Charles Brunicardi
Sep 28, 2012·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·A O Shpakov
Mar 3, 2015·Environmental Health and Preventive Medicine·N M Abdel-HamidK Thabet
Feb 5, 2021·Journal of Clinical Medicine·Maria Celeste CantoneGiovanni Vitale
Apr 27, 2021·Experimental Lung Research·Tatsuya HosonoYukihiko Sugiyama
Nov 17, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Valentina AmbrosiniStefano Fanti
Sep 24, 2021·Molecular Cancer Therapeutics·Célia CintasJulie Guillermet-Guibert

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Julie GuillermetCorinne Bousquet
Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Rosa TeijeiroVictor M Arce
Molecular and Cellular Endocrinology
Stéphane PyronnetChristiane Susini
© 2022 Meta ULC. All rights reserved