Novel syntheses of tetrahydrobenzodiazepines and dihydropyrazines via isocyanide-based multicomponent reactions of diamines

Journal of Combinatorial Chemistry
Ahmad ShaabaniSeik Weng Ng

Abstract

In this work, two novel isocyanide-based multicomponent reactions of 1,2-diamine compounds with diketene have been developed as efficient strategies for the synthesis of 2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-2-carboxamides with regiochemical control and 1,6-dihydropyrazine-2,3-dicarbonitriles in good to excellent yields at ambient temperature.

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Mar 14, 2009·Journal of Combinatorial Chemistry·Ahmad ShaabaniMaryam Behnam

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Citations

Feb 8, 2020·Neuropsychological Rehabilitation·Kosaku SunagawaRumi Tanemura
Mar 9, 2021·Organic & Biomolecular Chemistry· Preeti, Krishna Nand Singh
Apr 27, 2021·Organic & Biomolecular Chemistry·Hassan FarhidAhmad Shaabani
Jun 24, 2020·ACS Combinatorial Science·Mohammad Taghi NazeriAhmad Shaabani

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