Novel synthetic analogs of sialyl Lewis X can inhibit angiogenesis in vitro and in vivo

Biochemical and Biophysical Research Communications
M NguyenS Defrees

Abstract

Selectins have been shown to play an important role in angiogenesis. We have set out to synthesize multiple analogs of the selectin ligand sialyl Lewis X. We show here that analogs of sialyl Lewis X at concentrations of 50 micrograms/ml or greater significantly inhibited angiogenesis in in vitro assays of endothelial cell migration and proliferation (p < 0.05). These analogs also exerted significant inhibitory effects in in vivo angiogenesis assays using the chick chorioallantoic membrane at doses of 2 mg/chick or greater (p < 0.05). In contrast, the related carbohydrate Lewis X did not inhibit angiogenesis in both in vitro and in vivo assays. These data indicate that angiogenesis can be inhibited specifically by synthetic analogs of sialyl Lewis X. These analogs may potentially be useful in the treatment of angiogenesis-related diseases.

Citations

Jun 7, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Johanne SeguinGuy G Chabot
May 29, 2002·Hybridoma and Hybridomics·Magdalena Thurin, Thomas Kieber-Emmons
Feb 1, 1997·The Journal of Clinical Investigation·J Bischoff
Mar 7, 2000·The American Journal of Pathology·P Nangia-MakkerA Raz
Apr 19, 2002·Nutrition and Cancer·M R SartippourM Nguyen
Feb 21, 2007·Clinical Rheumatology·Anna Olewicz-GawlikPaweł Hrycaj
Dec 19, 2002·Journal of the National Cancer Institute·Pratima Nangia-MakkerAvraham Raz
Sep 30, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Víctor M Cárdenas DelgadoMaría T Elola
Jul 17, 1998·Current Opinion in Chemical Biology·K J Yarema, C R Bertozzi
Apr 3, 2002·Trends in Molecular Medicine·Pratima Nangia-MakkerAvraham Raz
Jun 27, 2002·Peptides·Insug OMagdalena Blaszczyk-Thurin
May 16, 2000·Biochemical Pharmacology·D F Ranney
Sep 25, 2007·Biochemical and Biophysical Research Communications·Eunju YangHo Jeong Kwon

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