Novel tamarind seed polysaccharide-alginate mucoadhesive microspheres for oral gliclazide delivery: in vitro-in vivo evaluation

Drug Delivery
Dilipkumar Pal, Amit Kumar Nayak

Abstract

Novel tamarind seed polysaccharide (TSP)-alginate mucoadhesive microspheres were prepared using TSP and alginate as blend in different ratios with different calcium chloride (CaCl(2)) concentration as a cross linker by ionotropic gelation. The prepared microspheres were of spherical shape having rough surfaces, and average particle sizes within the range of 752.12 ± 6.42 to 948.49 ± 20.92 µm. The drug entrapment efficiency of these microspheres were within the range between 58.12 ± 2.42 to 82.78 ± 3.43% w/w. Fourier transform infrared (FTIR) studies indicated that there were no reactions between gliclazide, and polymers (TSP, and sodium alginate) used. Different formulations of gliclazide loaded TSP-alginate microspheres showed prolonged in vitro release profiles of gliclazide over 12 hours in both stomach pH (pH 1.2), and intestinal pH (pH 7.4). It was found that the gliclazide release in gastric pH was comparatively slow and sustained than intestinal pH. These TSP-alginate microspheres also exhibited good mucoadhesivity. The in vivo studies on alloxan-induced diabetic rats (Animal Ethical Committee registration number: IFTM/837ac/0160) demonstrated the significant hypoglycemic effect of selected formulation of TSP-alginate mu...Continue Reading

References

Mar 8, 2000·International Journal of Biological Macromolecules·F LlanesR H Marchessault
Apr 4, 2003·International Journal of Pharmaceutics·Jaspreet Kaur VasirSanjay Garg
Sep 30, 2003·Applied Biochemistry and Biotechnology·Thomas A DavisAlfonso Mucci
Jun 17, 2004·AAPS PharmSciTech·Prashant M SatturwarAvinash K Dorle
Nov 2, 2004·Biological & Pharmaceutical Bulletin·Kora Pattabhi Rama Chowdary, Yarraguntla Srinivasa Rao
Aug 17, 2005·International Journal of Pharmaceutics·Pasquale Del GaudioFabio Sonvico
Jul 11, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Meera George, T Emilia Abraham
May 18, 2007·International Journal of Pharmaceutics·Raida S Al-KassasMonirah M Al-Faadhel
Nov 6, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Gavin P AndrewsDavid S Jones
Oct 20, 2010·Drug Delivery·Pankaj Padmakar Nerkar, Surendra Gattani

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Citations

Feb 19, 2004·Advanced Drug Delivery Reviews·Christiane BiesJohn F Woodley
Apr 26, 2005·Il Farmaco·Soliman Mohammadi-SamaniGolamhosein Yousefi
Sep 3, 2013·International Journal of Biological Macromolecules·Amit Kumar Nayak, Dilipkumar Pal
Sep 4, 2013·International Journal of Biological Macromolecules·Amit Kumar NayakM Saquib Hasnain
Jan 23, 2014·International Journal of Biological Macromolecules·Amit Kumar NayakKousik Santra
Jan 28, 2014·International Journal of Biological Macromolecules·Sougata JanaSanat Kumar Basu
Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·F MadsenJ D Smart
Nov 5, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·B KriwetT Kissel
Sep 2, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·D PatelJ D Smart
Oct 16, 1999·International Journal of Pharmaceutics·D J DobrozsiA A Sakr
Oct 18, 2016·Drug Delivery·Vineet Kumar RaiNarayan Prasad Yadav
Feb 20, 2015·Drug Delivery·Haiqun ZhangGuangxi Zhai
Jul 12, 2014·Artificial Cells, Nanomedicine, and Biotechnology·Armin MooranianHani Al-Salami
Jan 22, 2013·Colloids and Surfaces. B, Biointerfaces·Pravat Ranjan GuruRajendra Kumar Sahu
Feb 13, 2013·Colloids and Surfaces. B, Biointerfaces·Sougata JanaSanat Kumar Basu
Oct 17, 2015·International Journal of Biological Macromolecules·Amit Kumar NayakKousik Santra
Aug 6, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cade B FoxTejal A Desai
May 9, 2013·Expert Opinion on Drug Delivery·Radhika Poojari, Rohit Srivastava
May 27, 2015·International Journal of Biological Macromolecules·Amit Kumar NayakKousik Santra
May 20, 2015·International Journal of Biological Macromolecules·Priyanka SinhaBobba Rama
Mar 19, 2013·International Journal of Biological Macromolecules·Sougata JanaSanat Kumar Basu
May 1, 2013·International Journal of Biological Macromolecules·Amit Kumar Nayak, Dilipkumar Pal
Feb 18, 2014·Carbohydrate Polymers·Amit Kumar NayakKousik Santra
Dec 19, 2012·International Journal of Biological Macromolecules·Amit Kumar NayakM Saquib Hasnain
Jan 9, 2013·Advanced Materials·Steven W CranfordMarkus J Buehler
Oct 15, 2014·International Journal of Biological Macromolecules·Priyanka SinhaAmit Kumar Nayak
Oct 28, 2019·Therapeutic Delivery·Kamla Pathak
Sep 7, 2019·Current Pharmaceutical Design·Amit K NayakDong K Yi
Aug 12, 2020·Current Drug Delivery·Dhalendra KothaleDharmendra Jain
May 1, 2021·Journal of Functional Biomaterials·Tiziana Maria Grazia PecoraRosario Pignatello
Jun 13, 2017·International Journal of Biological Macromolecules·Dinanath GaikwadNamdeo Jadhav

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