Novel targeted agents for the treatment of advanced breast cancer

Future Medicinal Chemistry
Máximo de la VegaRicardo H Alvarez

Abstract

The discovery of the molecular processes involved in cancer development has led to the design of an array of targeted agents. These agents, directed to specific proteins in the machinery of cancer cells, interfere with vital cascades involved in cell invasion, metastasis, apoptosis, cell-cycle control and angiogenesis. In breast cancer, the main pathways studied and targeted by drugs are the HER2 pathway, EGFR, VEGF, PI3K/Akt/mammalian target of rapamycin (PI3K-M-Tor), IGF/IGFR, poly(ADP ribose) polymerase 1, HDAC and many others. In this review, we present the most promising studies of these new targeted therapies and novel combination of targeted therapies with cytotoxic agents for the treatment of breast cancer patients.

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Citations

Aug 12, 2014·International Journal of Molecular Sciences·Mohammad Hojjat-Farsangi
Jun 19, 2013·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Adilson Kleber FerreiraDurvanei Augusto Maria
Oct 27, 2015·Future Medicinal Chemistry·Nelly Fosu-MensahAndrew D Westwell
Jun 6, 2013·Bioorganic & Medicinal Chemistry·Mark E Welker, George Kulik
Sep 16, 2014·Neoplasia : an International Journal for Oncology Research·Tao ZhangZhengfang Yi
Jul 26, 2017·Environmental Science and Pollution Research International·Akkarasiri SangsawangKaren Thompson

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Methods Mentioned

BETA
xenograft
transgenic
biopsies
acetylation
transfection

Clinical Trials Mentioned

NCT01262027

Software Mentioned

CLEOPATRA
EMILIA
GEPARQUINTO
NeoALTTO
RiBBON

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