Novel targets for tuberculosis drug discovery

Current Opinion in Pharmacology
Khisimuzi Mdluli, Melvin Spigelman

Abstract

Since the determination of the Mycobacterium tuberculosis genome sequence, various groups have used the genomic information to identify and validate targets as the basis for the development of new anti-tuberculosis agents. Validation might include many components: demonstration of the biochemical activity of the enzyme, determination of its crystal structure in complex with an inhibitor or a substrate, confirmation of essentiality, and the identification of potent growth inhibitors either in vitro or in an infection model. If novel target validation and subsequent inhibition are matched by an improved understanding of disease biology, then new antibiotics could have the potential to shorten the duration of therapy, prevent resistance development and eliminate latent disease.

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Related Concepts

Ethambutol
Biochemical Pathway
Stringent Response
Derivatives
Genome
Mycolic Acids
Tuberculosis
Enzymes, antithrombotic
Antibiotic throat preparations
Pathogenic Organism

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