Novel targets in pancreatic cancer research

Seminars in Oncology
Geoffrey KozakJonathan R Brody

Abstract

The initiation and progression of pancreatic ductal adenocarcinoma (PDA) occurs as a result of molecular alterations that typically result in fluctuations of transcription, protein expression, and ultimately dysregulated signaling pathways. For example, PDA is driven by key activating, gain-of-function mutations in proto-oncogenes (eg, K-Ras) along with loss of function of tumor suppressor genes (eg, p16, SMAD4). With the advent of whole-exome sequencing of PDA genomes, several key genetic alterations have been identified as drivers of PDA. While these findings have led to groundbreaking discoveries in the etiology of PDA, they have failed to provide feasible, targetable therapeutic approaches. Additionally, recent advances in PDA research have uncovered the role of the tumor microenvironment (the non-epithelial tumor cells) in PDA progression by promoting potent, acute changes in gene expression. Herein, this chapter is aimed at discussing the key genetic and non-genetic mechanisms responsible for PDA initiation and progression. Thus based on these mechanisms, we will put forth investigated and novel therapeutic targets in PDA.

References

Feb 1, 1997·Molecular Pathology : MP·I ArielA Hochberg
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·A SaitoO Nakanishi
Sep 27, 2002·Molecular Carcinogenesis·Suhail AyeshAbraham Hochberg
Nov 14, 2002·The Biochemical Journal·Annemieke J M de RuijterAndré B P van Kuilenburg
Sep 25, 2004·Journal of Cellular Physiology·Roberta Di Pietro, Giorgio Zauli
Dec 8, 2004·Surgery Today·Tamotsu KurokiTakashi Kanematsu
Oct 26, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michiel S van der HeijdenScott E Kern
Jun 27, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Carsten DenkertWilko Weichert
May 22, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pamela MünsterAdil Daud
Jul 17, 2007·Nature Chemical Biology·Nicole-Claudia MeisnerManfred Auer
Jul 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Navneet DhillonRazelle Kurzrock
Aug 30, 2008·The International Journal of Biochemistry & Cell Biology·Rachel CoddAmalie A H Pakchung
Mar 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christine A Iacobuzio-DonahueDaniel Laheru
May 30, 2009·Journal of the American College of Surgeons·Agnieszka K WitkiewiczJonathan R Brody
Aug 27, 2009·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Sung-Jig LimSung Il Choi
Sep 22, 2009·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Ronald T CottonWilliam E Fisher
Nov 6, 2010·Journal of Oncology·V ScaiewiczA Czerniak
Jan 29, 2011·Journal of Gastrointestinal Cancer·Günter SchneiderDieter Saur
Mar 11, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·N V RajeshkumarManuel Hidalgo
May 26, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Audrey VincentMichael Goggins
Jun 7, 2011·The New England Journal of Medicine·Caroline RobertJedd D Wolchok
Sep 22, 2011·Wiley Interdisciplinary Reviews. RNA·Kotb Abdelmohsen, Myriam Gorospe
Oct 19, 2011·Future Medicinal Chemistry·Antonio T BainesChanning J Der
Jun 5, 2012·The New England Journal of Medicine·Suzanne L TopalianMario Sznol
Jun 20, 2012·Nature Reviews. Gastroenterology & Hepatology·Mert ErkanHelmut Friess
Aug 17, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Manuel Hidalgo, Daniel D Von Hoff
Aug 17, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christine FeigDavid A Tuveson

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Citations

Feb 14, 2016·Expert Opinion on Therapeutic Targets·Ruth NussinovOzlem Keskin
Jan 21, 2016·Acta Biochimica Et Biophysica Sinica·Shuai LiangYixiong Li
Jan 28, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Huizhong GanJianming Xu
Nov 21, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jing ZhangJun Wang
Jun 29, 2016·Molecular Carcinogenesis·Nan YouLu Zheng
Jun 17, 2015·Clinical Medicine Insights. Case Reports·Amgad N Makaryus, Lawrence Boxt
Apr 26, 2017·International Journal of Oncology·Eri BannoKazuto Nishio
Sep 11, 2018·Cancer Biomarkers : Section a of Disease Markers·Lin ZhuHong Yu
Mar 2, 2019·Journal of Translational Medicine·Fabio GrizziLuca Di Tommaso

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