Novel targets of ANG II regulation in mouse heart identified by serial analysis of gene expression

American Journal of Physiology. Heart and Circulatory Physiology
Faina SchwartzHaralambos Gavras

Abstract

Although the central role of ANG II in cardiovascular homeostasis is well appreciated, the molecular circuitry of its many actions is not completely understood. With the use of serial analysis of gene expression to assess global transcriptional changes in the heart of mice after continuous 7-day ANG II administration, we identified patterns of gene expression indicative of cardiac remodeling, including coordinate regulation of genes previously described in a context of processes associated with hypertrophy and fibrosis. In addition, we discovered several novel ANG II targets, including characterized genes of known function, recently annotated genes of unknown function, and the putative genes not yet present in current databases. The serial analysis of gene expression approach to assess the role of ANG II presented in this report provides new venues for inquiries into ANG II-mediated cardiac function.

Associated Datasets

Jul 22, 2004·Jing CuiIrena Duka

References

Nov 1, 1991·Circulation Research·L B TanK T Weber
Oct 24, 1985·The New England Journal of Medicine·J S IngwallP D Allen
Aug 1, 1968·The Journal of Clinical Investigation·B Wittels, J F Spann
Mar 2, 1972·The New England Journal of Medicine·H R BrunnerF R Bühler
Oct 20, 1995·Science·V E VelculescuK W Kinzler
Sep 1, 1996·Cardiovascular Research·F FarhadianL Rappaport
Dec 1, 1996·Hypertension·C JohnsH Gavras
Dec 31, 1997·The Journal of Clinical Investigation·K NakaoL A Leinwand
Jan 29, 1999·Physiological Reviews·B Swynghedauw
Mar 17, 1999·Biochimica Et Biophysica Acta·J W Taanman
May 25, 1999·Journal of Molecular and Cellular Cardiology·P Lijnen, V Petrov
Nov 24, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Q Yan, E H Sage
Jan 5, 2000·American Journal of Hypertension·M R Weir, V J Dzau
Mar 23, 2000·Cardiovascular Research·S HeinJ Schaper
Apr 25, 2000·Cardiovascular Research·J M Schnee, W A Hsueh
May 16, 2000·Circulation Research·L W StantonR T White
Jun 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·C J FriddleJ Bristow
Nov 30, 2000·Journal of Human Hypertension·M G Nicholls, J I Robertson
Feb 22, 2001·Science·J C VenterX Zhu
Mar 10, 2001·Nature·E S LanderUNKNOWN International Human Genome Sequencing Consortium
Mar 31, 2001·Novartis Foundation Symposium·D C Wallace
Apr 9, 2002·Lancet·Hans R Brunner, Haralambos Gavras
Apr 23, 2002·Journal of Human Hypertension·I Gavras, H Gavras
Aug 6, 2002·Genomics·Sergey V AnisimovKenneth R Boheler
Oct 3, 2002·Journal of Cell Science·Maureen G PriceHenry F Epstein
Nov 14, 2002·Physiological Genomics·M SteenmanJ J Léger
Nov 26, 2002·Biochimica Et Biophysica Acta·Marek MichalakMichal Opas
Dec 6, 2002·Nature·UNKNOWN Mouse Genome Sequencing ConsortiumEric S Lander
Dec 6, 2002·Nature·Y OkazakiUNKNOWN RIKEN Genome Exploration Research Group Phase I & II Team
Dec 31, 2002·Journal of Molecular and Cellular Cardiology·Arantxa GonzálezJavier Díez
Feb 8, 2003·Trends in Biotechnology·Kenneth R Boheler, Michael D Stern
Apr 5, 2003·American Journal of Physiology. Renal Physiology·Dennis Brown
Jul 17, 2003·Physiological Genomics·Burns C BlaxallWalter J Koch
Aug 7, 2003·Physiological Genomics·Maria MirotsouVictor J Dzau
Oct 23, 2003·Physiological Genomics·Faina SchwartzHaralambos Gavras
Feb 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kathleen M I CaronOliver Smithies

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Citations

Mar 6, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Vijaykumar S KasiSamuel C Dudley
Feb 27, 2010·American Journal of Hypertension·Maria MarketouHaralambos Gavras
Aug 19, 2007·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Wael M MaharsyAnwar B Bikhazi
May 28, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Athanasios J ManolisHaralambos Gavras

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