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Novel tau filament fold in corticobasal degeneration, a four-repeat tauopathy

bioRxiv

Oct 21, 2019

Wen-Juan ZhangSjors H. W. Scheres

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Abstract

Corticobasal degeneration (CBD) is a neurodegenerative tauopathy that is characterised by motor and cognitive disturbances. A higher frequency of the H1 haplotype of MAPT, the tau gene, is present in cases of CBD than in controls and genome-wide association studies have identified addit...read more

Mentioned in this Paper

Alzheimer's Disease
Brain
Lysine
Electron Microscopy
Tau Proteins
Pick Disease of the Brain
Binding Protein
Corticobasal Degeneration
14-3-3 Protein, tau Isoform
Protein Isoforms
66
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Novel tau filament fold in corticobasal degeneration, a four-repeat tauopathy

bioRxiv

Oct 21, 2019

Wen-Juan ZhangSjors H. W. Scheres

DOI: 10.1101/811703

Abstract

Corticobasal degeneration (CBD) is a neurodegenerative tauopathy that is characterised by motor and cognitive disturbances. A higher frequency of the H1 haplotype of MAPT, the tau gene, is present in cases of CBD than in controls and genome-wide association studies have identified addit...read more

Mentioned in this Paper

Alzheimer's Disease
Brain
Lysine
Electron Microscopy
Tau Proteins
66

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