PMID: 9647415Jul 1, 1998Paper

Novel technetium-99m-labeled platelet GPIIb/IIIa receptor antagonists as potential imaging agents for venous and arterial thrombosis

Coronary Artery Disease
S A MousaJ Barrett

Abstract

Either venous or arterial thrombosis is a potentially life-threatening event and existing diagnostic modalities are inadequate to diagnose and to determine the morphology of the evolving thrombus. Thus development of a noninvasive imaging agent that can detect clot location remains a critical and unmet need in nuclear diagnostic medicine. The present study was undertaken to determine the potential of platelet GPIIb/IIIa receptors compared with direct thrombin inhibitors, in the detection of venous and arterial clots. Initially, the validity of exploiting the degree and extent of specific uptake and retention of a potent GPIIb/IIIa receptor antagonist in venous and in arterial thrombus was confirmed in vitro in artificially created arterial- or venous-type clots, using the radiolabeled antagonist, 3H-DMP728. This was followed by comparing the in-vivo clot/blood distribution of various technetium-99m (99mTc)-labeled, DMP728-derived, GPIIb/IIIa receptor antagonists and of thrombin inhibitors, over time, in mixed arterial/venous or venous clots in arteriovenous shunt and in venous clot models in dogs. In addition, we performed noninvasive single-photon emission tomographic imaging of the venous clot in a deep vein thrombosis model ...Continue Reading

Citations

Dec 21, 2007·Molecular Biotechnology·Shaker A Mousa
Mar 13, 1999·Thrombosis Research·J Hauptmann, J Stürzebecher
Jul 23, 2002·Current Opinion in Chemical Biology·Shaker A Mousa
Nov 20, 2003·Seminars in Nuclear Medicine·Daniel F Worsley, Abass Alavi
Oct 6, 2001·Radiologic Clinics of North America·D F Worsley, A Alavi
Jun 14, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Gregory M LanzaXiaoxia Yang

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