Novel technologies and emerging biomarkers for personalized cancer immunotherapy

Journal for Immunotherapy of Cancer
Jianda YuanBernard A Fox

Abstract

The culmination of over a century's work to understand the role of the immune system in tumor control has led to the recent advances in cancer immunotherapies that have resulted in durable clinical responses in patients with a variety of malignancies. Cancer immunotherapies are rapidly changing traditional treatment paradigms and expanding the therapeutic landscape for cancer patients. However, despite the current success of these therapies, not all patients respond to immunotherapy and even those that do often experience toxicities. Thus, there is a growing need to identify predictive and prognostic biomarkers that enhance our understanding of the mechanisms underlying the complex interactions between the immune system and cancer. Therefore, the Society for Immunotherapy of Cancer (SITC) reconvened an Immune Biomarkers Task Force to review state of the art technologies, identify current hurdlers, and make recommendations for the field. As a product of this task force, Working Group 2 (WG2), consisting of international experts from academia and industry, assembled to identify and discuss promising technologies for biomarker discovery and validation. Thus, this WG2 consensus paper will focus on the current status of emerging bio...Continue Reading

References

Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·U SahinM Pfreundschuh
Dec 1, 1995·Current Opinion in Cell Biology·G M Keller
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·Y T ChenL J Old
Jun 23, 1998·Quarterly Reviews of Biophysics·P James
Oct 8, 1999·Immunity·E Gilboa
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S A KusmartsevS H Chen
Feb 27, 2001·Nature Immunology·Y LatchmanG J Freeman
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·V G TusherG Chu
Jan 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alessandra MazzoniDavid M Segal
Mar 26, 2002·Nature Reviews. Immunology·Carol L Vanderlugt, Stephen D Miller
May 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·Robert TibshiraniGilbert Chu
Nov 28, 2002·Nature Genetics·John Quackenbush
Jun 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Giao Q PhanSteven A Rosenberg
Aug 22, 2003·Nature·Alison Abbott
Apr 6, 1957·British Medical Journal·M BURNET
Nov 5, 2003·Methods : a Companion to Methods in Enzymology·Gordon K Smyth, Terry Speed
Mar 25, 2004·Trends in Biotechnology·Jens M Kelm, Martin Fussenegger
Nov 2, 2004·Nature Reviews. Cancer·Margareta M Mueller, Norbert E Fusenig
Aug 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter AttiaSteven A Rosenberg
Apr 25, 2006·Biostatistics·W Evan JohnsonAriel Rabinovic
Jun 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Masahisa JinushiGlenn Dranoff
Jun 27, 2006·Journal of Immunotherapy·Ajay V MakerSteven A Rosenberg
Jul 5, 2006·The Journal of Experimental Medicine·Weihong LiuJeffrey A Bluestone
Feb 10, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Deirdre O'MahonyJohn E Janik
Feb 23, 2007·Nature·Vanessa Gray-SchopferRichard Marais
May 31, 2007·The Journal of Experimental Medicine·Melissa L PrecopioRichard A Koup
Aug 9, 2007·Nature Reviews. Molecular Cell Biology·Francesco PampaloniErnst H K Stelzer
Sep 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·James E Talmadge
Oct 6, 2007·Molecular & Cellular Proteomics : MCP·Juan Madoz-GúrpideSam M Hanash
Nov 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Laura StraussTheresa L Whiteside
Jan 5, 2008·Annual Review of Immunology·Mary E KeirArlene H Sharpe
Feb 19, 2008·Nature Biotechnology·Gary K GeissKrassen Dimitrov
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·F Stephen HodiGlenn Dranoff
Mar 8, 2008·Nature Reviews. Immunology·Robert A SederMario Roederer
May 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Raanan BergerArnon Nagler
Jun 3, 2008·Genomics·You-Jia HuaHua-Sheng Xiao
Aug 5, 2008·Statistical Applications in Genetics and Molecular Biology·Youlan RaoJohn P Hagan

❮ Previous
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Citations

Aug 31, 2019·Expert Review of Molecular Diagnostics·Ernest Y Lee, Rajan P Kulkarni
Aug 18, 2016·Journal for Immunotherapy of Cancer·Jianda Yuan
Jun 30, 2016·The Oncologist·Leora HornDavid R Spigel
Jul 6, 2019·Current Medicinal Chemistry·Snježana KaštelanKoraljka Hat
Mar 20, 2018·Oncotarget·Riccardo MarconciniUNKNOWN Italian Melanoma Intergroup (IMI)
Sep 21, 2018·Molecular and Clinical Oncology·Marco DanovaGiuliano Mazzini
Aug 28, 2020·Expert Review of Anticancer Therapy·Saharnaz PezeshkiNima Rezaei
Mar 24, 2017·Journal for Immunotherapy of Cancer·David F StroncekBarbara Seliger
Jun 18, 2016·Current Treatment Options in Oncology·Panagiota EconomopoulouAmanda Psyrri
Jul 21, 2016·Journal for Immunotherapy of Cancer·Leisha A EmensHoward L Kaufman
Dec 9, 2016·Vaccines·Nicole E Scharping, Greg M Delgoffe
Feb 9, 2017·Nature Medicine
Jul 18, 2017·Proteomics·Els MeeusenSuresh Mathivanan
Jul 12, 2018·Current Opinion in Oncology·Giovanni FucàMassimo Di Nicola
Sep 5, 2018·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jessica Da Gama DuarteJonathan M Blackburn
Sep 8, 2018·The Journal of Pathology. Clinical Research·Marieke E IjsselsteijnNoel Fcc de Miranda
Mar 3, 2019·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Olivier BylickiChristos Chouaïd
Jul 19, 2016·Expert Review of Clinical Immunology·Kathryn E BeckermannJeffrey A Sosman
Oct 30, 2016·Genome Medicine·Daphne Day, Lillian L Siu
Nov 26, 2016·Cancers·Smitha MenonGrace Dy
Nov 30, 2016·Journal for Immunotherapy of Cancer·Giuseppe V MasucciMagdalena Thurin
Jun 28, 2017·Journal for Immunotherapy of Cancer·James L GulleyLisa H Butterfield
Sep 22, 2018·Biology of the Cell·Frederic DelomDelphine Fessart
Jun 22, 2018·Critical Reviews in Clinical Laboratory Sciences·Karolina OklaJan Kotarski
Jun 23, 2016·Journal for Immunotherapy of Cancer·Howard L KaufmanFrancesco M Marincola
Dec 21, 2016·Targeted Oncology·Juan Martin-LiberalJordi Rodon
Oct 27, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Eva ZupančičWillem J M Mulder
Feb 3, 2018·Immunology and Cell Biology·Jessica da Gama DuarteAndreas Behren
Jun 13, 2017·Expert Review of Anticancer Therapy·Aine O'reilly, James Larkin
May 23, 2017·Neuro-oncology·Anna Sophie BerghoffMatthias Preusser
Nov 7, 2017·Nature Reviews. Neurology·Lidia M YshiiRoland S Liblau
Aug 23, 2017·Medical Oncology·Alissar El ChediakYoussef H Zeidan
Jul 14, 2018·Biomedicines·Lorenzo Pilla, Cristina Maccalli
Jun 14, 2018·Frontiers in Oncology·Sabrina A HoganPhil F Cheng

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Methods Mentioned

BETA
biopsy
flow cytometry
exome sequencing
biopsies
PCR
ELISA
scanning electron microscopy

Software Mentioned

SVA
JointSNVMix
TEPITOPEpan
R
Epiontis
SomaticSniper
ProtoArray®
Strelka
Multipred2
MultiRTA

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