Novel testis-specific protein that interacts with heat shock factor 2

Gene
T YoshimaH Yanagi

Abstract

Although heat shock factor 2 (HSF2) binds to heat shock element (HSE) constitutively during differentiation, development and spermatogenesis, little is known about the nature and mechanism of transcriptional control of heat shock genes by HSF2. We screened a human testis cDNA library for proteins that can associate with HSF2 by the yeast two-hybrid system, and isolated clones encoding a novel protein, designated HSF2 binding protein (HSF2BP), that associates with HSF2 in vitro and in vivo and is specifically expressed in testis. The interaction seemed to occur between the trimerization domain of HSF2 and the amino terminal hydrophilic region of HSF2BP that comprises two leucine zipper motifs. HSF2BP may therefore be involved in modulating HSF2 activation in testis.

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Citations

Feb 5, 2008·Yi chuan = Hereditas·Shao-Qin GeShu-Mei Mu
Jan 22, 2020·Nucleic Acids Research·Koichi SatoAlex N Zelensky
May 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·L PirkkalaL Sistonen
Jan 27, 2019·Science·Bjarni V HalldorssonKari Stefansson
May 29, 2020·Nucleic Acids Research·Yongliang ShangLiangran Zhang
Aug 28, 2021·Genes·Hang Phuong LeJie Liu

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