Novel tetrahydro-thieno pyridyl oxazolidinone: an antibacterial agent

Bioorganic & Medicinal Chemistry
Braj Bhushan LohrayPurvi Pandya

Abstract

Synthesis of a number of 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine substituted oxazolidinones have been reported. They have been screened against a panel of Gram-positive pathogens including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis. A SAR has been developed. Compound 15 showed comparable activity (MIC) to linezolid and superior to eperezolid.

References

Sep 1, 1978·Journal of Medicinal Chemistry·S CondeJ del Río
Apr 8, 2003·Current Topics in Medicinal Chemistry·Douglas K Hutchinson
Jul 9, 2003·Drugs of Today·Y Q XiongA S Bayer
Nov 19, 2003·Bioorganic & Medicinal Chemistry Letters·Steven D PagetMark J Macielag
May 20, 2004·Bioorganic & Medicinal Chemistry Letters·Braj Bhushan LohrayPurvi Pandya

❮ Previous
Next ❯

Citations

Aug 11, 2011·Chemical Communications : Chem Comm·Nadia E A El-GamelSanjay Mathur
Apr 19, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohsine DriowyaKhalid Bougrin
Jun 25, 2013·Journal of Molecular Graphics & Modelling·Behzad ChahkandiMohammad Chahkandi
Jan 3, 2006·Bioorganic & Medicinal Chemistry Letters·Braj Bhushan LohrayPrashant Kapadnis
Oct 27, 2004·European Journal of Medicinal Chemistry·Brijesh Kumar SrivastavaVidya Bhushan Lohray
Aug 28, 2014·Acta Crystallographica. Section E, Structure Reports Online·Mehmet AkkurtMustafa R Albayati
Jan 25, 2013·Bioorganicheskaia khimiia·Meltem YolalAhmet Demirbas
May 23, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Nadia E A El-Gamel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacillus Cereus Infection

Bacillus Cereus is a gram-positive bacteria that is the cause of some foodborne illnesses and leads to diarrhea and vomiting. Discover the latest research on Bacillus Cereus Infection here.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Related Papers

Bioorganic & Medicinal Chemistry Letters
Braj Bhushan LohrayPurvi Pandya
Bioorganic & Medicinal Chemistry Letters
Steven D PagetMark J Macielag
© 2021 Meta ULC. All rights reserved