Novel therapeutic strategies and perspectives for metastatic pancreatic cancer: vaccine therapy is more than just a theory

Cancer Cell International
Wenhao LuoTaiping Zhang

Abstract

Pancreatic cancer is an aggressive and malignant tumor with an exceedingly high mortality rate. The quality of life and survival rates of pancreatic cancer patients with metastasis are poor compared with those without metastasis. Thus far, no effective treatment strategy has been established for metastatic pancreatic cancer patients. Therefore, an appropriate therapeutic method based on the elimination of metastatic pancreatic cancer is critical to improve patient outcome. Tumor-targeted vaccines have been widely discussed in recent studies and enabled important breakthroughs in the treatment of pancreatic cancer by preventing the escape of tumor cells from immune surveillance and activating the immune system to eliminate cancer cells. T cells can be activated by the stimulation of tumor-targeted vaccines, but to mount an effective immune response, both immune checkpoint inhibitors and positive costimulatory molecules are required. In this review, we discuss potential tumor-targeted vaccines that can target pancreatic cancer, elaborate the probably appropriate combination of vaccines therapy and evaluate the underlying benefits as well as obstacles in the current therapy for metastatic pancreatic cancer.

References

Feb 8, 1996·International Journal of Cancer. Journal International Du Cancer·M K GjertsenG Gaudernack
Jun 17, 2006·The Journal of Clinical Investigation·Sergio A QuezadaJames P Allison
Apr 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Takeo NomiYoshiyuki Nakajima
Dec 5, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Craig D Logsdon, Baoan Ji
Aug 13, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Krithika N KodumudiJulie Y Djeu
Nov 16, 2010·Progress in Molecular Biology and Translational Science·Andrew D Rhim, Ben Z Stanger
Dec 17, 2010·Journal of Internal Medicine·K PaluckaJ Banchereau
Mar 20, 2012·Carcinogenesis·Zvi G Fridlender, Steven M Albelda
Mar 23, 2012·Nature Reviews. Cancer·Andrew M ScottLloyd J Old
May 4, 2012·Nature·Carson C ThoreenDavid M Sabatini
May 18, 2012·Science Translational Medicine·Andrew J RechRobert H Vonderheide
Feb 16, 2013·Cancer Cell·Giovanni GermanoPaola Allavena
Mar 6, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert H Vonderheide, Martin J Glennie
Jan 15, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dung T LeElizabeth M Jaffee
Mar 17, 2015·Trends in Immunology·Renato OstuniGioacchino Natoli
May 6, 2015·Drugs·Sohita Dhillon
Jan 12, 2016·Therapeutic Advances in Medical Oncology·Gregory T WurzMichael W DeGregorio
Mar 1, 2016·Advances in Immunology·Jeffrey P WardRobert D Schreiber
Jul 23, 2016·Nature Reviews. Cancer·Alvin Makohon-Moore, Christine A Iacobuzio-Donahue
Jul 28, 2016·Vaccine·Xiuli ZhangWilliam E Gillanders
Sep 21, 2016·Nature Immunology·Qi ChenZhijian J Chen
Nov 20, 2016·International Journal of Cancer. Journal International Du Cancer·Motoki MiyazawaHiroki Yamaue
Apr 9, 2017·Journal of Hematology & Oncology·Shikhar MehrotraDavid J Cole
Sep 1, 2017·Cancer Immunology, Immunotherapy : CII·Fee BengschGregory L Beatty
Jan 6, 2018·Cancers·Neus Martinez-BoschPilar Navarro
Aug 2, 2018·The Journal of Clinical Investigation·Aleksandra PopovicNeeha Zaidi
Feb 13, 2019·The Journal of Clinical Investigation·Alex B BlairLei Zheng
May 28, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dung T LeElizabeth M Jaffee
Aug 11, 2019·Proceedings of the National Academy of Sciences of the United States of America·Shigeru HashimotoHisataka Sabe
Aug 20, 2019·The Journal of Clinical Investigation·Polina WeitzenfeldJeffrey V Ravetch
Sep 19, 2019·Biomaterials Science·May Tun SaungHai-Quan Mao

❮ Previous
Next ❯

Citations

May 14, 2020·International Journal of Molecular Sciences·Michael Karl MelzerAlexander Kleger
Feb 7, 2021·Journal of Clinical Medicine·Andres Garcia-SampedroPilar Acedo

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection

Clinical Trials Mentioned

NCT02672917

Software Mentioned

Promote

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Related Papers

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Anna S Gukovskaya, Stephen J Pandol
Biochimica Et Biophysica Acta
Xianjun YuMin Li
JOP : Journal of the Pancreas
Muhammad Wasif Saif
Iranian Journal of Radiology : a Quarterly Journal Published by the Iranian Radiological Society
Li Na ShiQuan Yong Luo
[Rinshō ketsueki] The Japanese journal of clinical hematology
Nakamura Takafumi
© 2021 Meta ULC. All rights reserved