Novel therapeutic strategy in the management of COPD: a systems medicine approach

Current Medicinal Chemistry
Filippo LococoPatrizia Russo

Abstract

Respiratory diseases including chronic-obstructive-pulmonary-disease (COPD) are globally increasing, with COPD predicted to become the third leading cause of global mortality by 2020. COPD is a heterogeneous disease with COPD-patients displaying different phenotypes as a result of a complex interaction between various genetic, environmental and life-style factors. In recent years, several investigations have been performed to better define such interactions, but the identification of the resulting phenotypes is still somewhat difficult, and may lead to inadequate assessment and management of COPD (usually based solely on the severity of airflow limitation parameter FEV1). In this new scenario, the management of COPD has been driven towards an integrative and holistic approach. The degree of complexity requires analyses based on large datasets (also including advanced functional genomic assays) and novel computational biology approaches (essential to extract information relevant for the clinical decision process and for the development of new drugs). Therefore, according to the emerging "systems/network medicine", COPD should be re.-evaluated considering multiple network(s) perturbations such as genetic and environmental changes...Continue Reading

Citations

Jun 2, 2018·Current Medicinal Chemistry·Patrizia RussoMassimo Fini
Feb 26, 2019·Current Pharmaceutical Design·Ranjith Kumar KankalaAi-Zheng Chen
May 24, 2017·International Journal of Molecular Medicine·Zhenyu ShenShenghua Sun

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