Novel therapeutic targets in osteoporosis

Expert Opinion on Therapeutic Targets
J H TobiasA M Scutt

Abstract

Osteoporosis is a common condition in which significant bone loss occurs resulting in an increased risk of sustaining fractures. Several licensed therapies are available to treat this condition, which suffer from several disadvantages including limited efficacy, high cost and poor long-term patient adherence as a consequence of significant side effects and inconvenient methods of administration. A wide range of therapeutic targets have been developed to provide a basis for developing newer therapies which overcome these limitations. These can be subdivided into those that are primarily directed towards inhibiting osteoclast-dependent bone resorption and those that stimulate osteoblastic bone formation. Targets can be grouped as follows: systemic factors such as steroid and peptide hormones; local factors produced in bone involved in osteoblast and osteoclastic regulation; and cellular targets such as cell membrane receptors and attachment proteins, cellular enzymes and nuclear transcription factors. To date, only a small proportion of these targets have yielded novel compounds to have entered clinical trials. However, it is anticipated that these will provide the basis for significant numbers of new therapies for osteoporosis i...Continue Reading

References

Jan 1, 1992·Endocrinology·A M Flanagan, T J Chambers
Dec 3, 1992·The New England Journal of Medicine·M C ChapuyP J Meunier
Feb 6, 1992·The New England Journal of Medicine·M W TilyardS Dovey
Jan 1, 1991·Hormone Research·R Bouillon
Jan 1, 1990·Annual Review of Nutrition·T SudaN Takahashi
Oct 1, 1990·The Journal of Cell Biology·M SatoR J Gould
Feb 1, 1990·The Journal of Clinical Endocrinology and Metabolism·R MarcusB M Sherman
Apr 1, 1990·Metabolism: Clinical and Experimental·M K Drezner, T Nesbitt
Jun 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K BrixenA Flyvbjerg
Jun 1, 1989·Endocrinology·M Noda, J J Camilliere
Jan 1, 1985·Skeletal Radiology·A K PoznanskiT E Berry
Jan 1, 1982·The Journal of Pathology·T J Chambers, C J Magnus
Jul 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·W B BowlerG Bilbe
Jan 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M LiR B Setterberg
Mar 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A Scutt, P Bertram
Jul 1, 1994·Journal of Cellular Biochemistry·S R Siddhanti, L D Quarles
Sep 1, 1993·Cell Adhesion and Communication·A SuzukiO Kozawa
Jun 1, 1993·Calcified Tissue International·T TakagiH Tamaki
Jun 10, 1996·Archives of Internal Medicine·I R ReidJ P Stapleton
May 24, 1996·The Journal of Biological Chemistry·F H DrakeM Gowen
Mar 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R D WelchR H Browne
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·G G KuiperJ A Gustafsson
Feb 1, 1996·Calcified Tissue International·S Shimegi

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Citations

Nov 10, 2006·Journal of Neurophysiology·Rahul Gupta, James Ashe
Aug 30, 2008·Journal of Neurophysiology·Priska GysinAndrew M Gordon
Sep 5, 2008·Journal of Neurophysiology·Olivier WhiteJörn Diedrichsen
Nov 23, 2007·Journal of Neurophysiology·D KourtisP Praamstra

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