Novel therapeutics for bronchopulmonary dysplasia

Current Opinion in Pediatrics
Lannae Strueby, Bernard Thébaud

Abstract

This review provides a concise summary of recent literature pertaining to emerging therapies for bronchopulmonary dysplasia (BPD). To provide context for the presented therapies, a brief overview of recently proposed changes to the definition of BPD and the concept of expanded respiratory outcomes is included. New or redefined respiratory outcomes are required to improve accuracy in evaluating new therapies and correlating results with long-term clinical outcomes of importance. Dexamethasone is no longer the only steroid-based therapy showing promise for impacting BPD. Early trials indicate hydrocortisone, inhaled budesonide, and a budesonide-surfactant combination may be of benefit to preterm infants. Additionally, simple approaches like increasing utilization of mother's own milk may deserve more emphasis. Of significant interest is the traction stem cell therapies are acquiring as one of the more anticipated treatments for BPD. A new preclinical meta-analysis demonstrates the benefits of mesenchymal stromal cell therapy in animal models while the results of early clinical trials remain eagerly awaited. BPD continues to be the most frequently occurring significant morbidity for extremely preterm infants, yet highly effective ...Continue Reading

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Citations

May 20, 2020·European Journal of Pediatrics·Giulia VizzariMaria Lorella Giannì
Jul 27, 2020·F1000Research·Mitali Sahni, Vineet Bhandari
Sep 17, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Luc J I ZimmermannSilke Mader

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