Novel Therapeutics in Psoriatic Arthritis. What Is in the Pipeline?

Current Rheumatology Reports
Ofir Elalouf, Vinod Chandran

Abstract

To highlight the recently approved therapeutic agents in psoriatic arthritis (PsA), drugs in the pipeline, as well as to discuss efficacy with regard to different clinical domains of PsA. More than 15 years ago, tumor necrosis factor inhibitors (TNFi) were the first biologic disease modifying anti-rheumatic drugs (bDMARDs) that were approved for the treatment of PsA. Since then, multiple new therapeutic agents inhibiting other targets have emerged including biologics targeting interleukin (IL) 12/23, and IL 17 and oral agents targeting phosphodiesterase 4 (PDE4) and Janus kinases (JAKs). Many new agents with various modes of action including selective inhibition of IL 23, therapies promoting activated T cell apoptosis, inhibition of tyrosine kinase 2 (TYK2), and more are under active assessment in ongoing clinical trials. Effective therapies for treating PsA have emerged over the last 15 years and newer agents continue to be discovered, allowing greater therapeutic options for controlling psoriatic disease activity and preventing joint damage and disability. Personalized therapy for patients with PsA is now a possibility.

References

Aug 10, 2012·The New England Journal of Medicine·Ronald F van VollenhovenUNKNOWN ORAL Standard Investigators
Jun 12, 2014·The New England Journal of Medicine·Philip J MeaseAjay Nirula
Jul 10, 2014·The New England Journal of Medicine·Richard G LangleyUNKNOWN FIXTURE Study Group
Oct 1, 2015·The New England Journal of Medicine·Philip J MeaseUNKNOWN FUTURE 1 Study Group
Mar 9, 2017·The New England Journal of Medicine·Christopher T RitchlinDafna D Gladman
Apr 20, 2017·The New England Journal of Medicine·Kim A PappSteven J Padula
Oct 19, 2017·The New England Journal of Medicine·Dafna GladmanKeith S Kanik
Oct 19, 2017·The New England Journal of Medicine·Philip MeaseKeith S Kanik

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Citations

Jan 10, 2019·Expert Opinion on Therapeutic Patents·Xingrui HeXiang-Yang Ye
Feb 15, 2020·Expert Opinion on Pharmacotherapy·Francesco CasoLuisa Costa
Mar 8, 2019·Journal of Cutaneous Medicine and Surgery·Yang Qin, Renée A Beach
Oct 18, 2018·Praxis·Christina Ryser, Adrian Ciurea

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