Novel therapies in peripheral T-cell lymphomas.

Current Oncology Reports
Hilary M O'Leary, K J Savage

Abstract

Peripheral T-cell lymphomas (PTCLs) are a rare and heterogeneous group of disorders associated with a very poor prognosis. Historically, treatment protocols have been largely based on regimens used to treat aggressive B-cell lymphomas; unfortunately, the efficacy of these regimens has been suboptimal, with most patients experiencing relapse after initial therapy. An improved understanding of the molecular biology, pathogenesis, and progression of these disorders has led to the development of a variety of novel targeted agents that may improve outcomes in patients with PTCLs. The purpose of this review is to focus on these novel agents and the various treatment approaches that are currently being evaluated in PTCLs.

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Citations

Jan 20, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Owen A O'ConnorSteven Horwitz
Jun 24, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Owen A O'ConnorAndrei Shustov
Feb 18, 2017·Clinical Lymphoma, Myeloma & Leukemia·Eric D HsiFrancine M Foss
Feb 13, 2016·The American Journal of Surgical Pathology·Mariko YabeRoberto N Miranda
Mar 25, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hyon-Zu LeeRichard Pazdur

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B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

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