Novel therapies of multidrug-resistant Pseudomonas aeruginosa and Acinetobacter spp. infections: the state of the art

Archivum Immunologiae Et Therapiae Experimentalis
Marta Wróblewska

Abstract

Gram-negative non-fermenting bacilli, particularly Pseudomonas aeruginosa and Acinetobacter spp., are important opportunistic pathogens in hosppitalized patients, contributing to their morbidity and mortality. Recently, a rapid increase in frequency of multidrug-resistant clinical strains is being recorded, making the available therapeutic options very limited. Apart from the development of novel classes of antimicrobials, there is renewed interest in the use of old agents or new combinations of available drugs. Numerous in vitro investigations have been reported on the efficacy of different antimicrobials; however, they should be evaluated in experimental infection models and clinical trials. Novel approaches are being investigated, such as inhibition of virulence factor expression by pathogens or inhibition of their metabolic pathways. The use of bacteriophages, particularly those genetically modified, remains an alternative option in the therapy of infections caused by multidrug-resistant strains. Several vaccines against P. aeruginosa are under development. Apart from therapy with antimicrobial agents, eradication of outbreaks comprises implementation of strict infection control measures and prudent use of antimicrobials.

Citations

Jul 11, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A VieiraA Almeida
Sep 25, 2012·Research in Microbiology·Petar KnezevicLjiljana Vlaski
Apr 14, 2010·Research in Microbiology·Nien-Tsung LinMeng-Jiun Lai
Oct 3, 2006·Expert Review of Anti-infective Therapy·Paolo Grossi, Daniela Dalla Gasperina
Sep 5, 2012·Expert Review of Anti-infective Therapy·Kateryna Volodymyrivna Kon, Mahendra Kumar Rai
Jan 10, 2017·Frontiers in Microbiology·Stanley de S L GalvãoValério Monteiro-Neto

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