Novel thermo/pH sensitive nanogels composed from poly(N-vinylcaprolactam) for controlled release of an anticancer drug

Colloids and Surfaces. B, Biointerfaces
K Madhusudana RaoM C S Subha

Abstract

A series of novel nanogels (NGs) with both pH and thermoresponsive properties were synthesised by free radical emulsion polymerisation of N-vinyl caprolactam (VCL) and acrylamidoglycolic acid (AGA). 5-Flurouracil, an anti cancer drug, was successfully loaded into these nanogels via equilibrium swelling method. The encapsulation efficiency of 5-FU was found up to 61%. Here we present the novel potential drug delivery system showing both pH and temperature release of 5-FU. Fourier transforms infrared spectroscopy (FTIR), and differential scanning calorimetric (DSC) examined the structure and morphology of the NGs. Transmission electron microscopy (TEM) indicates the diameter of the NGs to be about 50 nm. The size distribution of NGs was investigated using dynamic light scattering (DLS), the average diameter and polydispersity is 57 nm and 0.194. Interestingly, the in vitro release studies of 5-FU demonstrated the dual nature (pH and temperature) of NGs. The cumulative release data were analysed using an emperical equation to compute the diffusion exponent (n); whose values suggest Fickian diffusion.

References

Jan 1, 1990·Pharmacology & Therapeutics·W B Parker, Y C Cheng
May 23, 2001·Advanced Drug Delivery Reviews·J Siepmann, N A Peppas
Mar 4, 2003·Nature Reviews. Drug Discovery·J Milton Harris, Robert B Chess
May 25, 2005·Angewandte Chemie·María J VicentRuth Duncan
Sep 7, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Sun Hwa KimTae Gwan Park
Mar 2, 2006·Journal of the American Chemical Society·Jun Wu, Adi Eisenberg
Feb 13, 2007·Nanomedicine : Nanotechnology, Biology, and Medicine·Catarina Pinto ReisFrancisco Veiga
Dec 17, 2011·Bioconjugate Chemistry·Neha BhucharRavin Narain

❮ Previous
Next ❯

Citations

Oct 20, 2015·Therapeutic Delivery·Yajing WangLin Ma
Oct 30, 2014·Advanced Healthcare Materials·Ji LiuChristine Jérôme
Dec 11, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Xiaomo LiLiping Guo
Jul 31, 2013·Colloids and Surfaces. B, Biointerfaces·Tao JiangRen-Xi Zhuo
May 3, 2015·Carbohydrate Polymers·Somkamol ManchunPornsak Sriamornsak
Aug 27, 2013·Colloids and Surfaces. B, Biointerfaces·Rajavelu Murali SankarSellamuthu N Jaisankar
Dec 22, 2014·International Journal of Pharmaceutics·K Madhusudana RaoChang-Sik Ha
Aug 16, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Marjan GhorbaniAli Akbar Entezami
Jul 8, 2016·Journal of Biomaterials Science. Polymer Edition·Parveen KumarMadhu Chopra
Jun 28, 2016·Experimental and Therapeutic Medicine·Jisheng GaoJinfeng Liu
Jun 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Young-Jin Kim, Yukiko T Matsunaga
Jan 25, 2016·Gels·Kummara Madhusudana RaoChang-Sik Ha

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.