Novel thiophenes and analogues with anthelmintic activity against Haemonchus contortus

Bioorganic & Medicinal Chemistry Letters
Isabel C GonzalezCharles K Smith

Abstract

A new series of analogues of 4-(4-fluorophenyl)-2-methylthio-thiophene-3-carbonitrile (1) were synthesized and evaluated for their in vitro and in vivo anthelmintic activity against Haemonchus contortus.

Citations

Oct 1, 2007·Expert Opinion on Drug Discovery·Debra J WoodsTimothy Geary
Nov 22, 2011·Veterinary Parasitology·Jacqueline B MatthewsFrank Jackson
Mar 28, 2008·Chemistry : a European Journal·Christoph A Fleckenstein, Herbert Plenio
Nov 28, 2006·Journal of Helminthology·J M de GruijterA M Polderman
Apr 18, 2009·The Journal of Organic Chemistry·Kenneth M EngstromSeble Wagaw
Sep 24, 2009·Journal of Medicinal Chemistry·Sébastien LethuJoëlle Dubois

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Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.