Novel tools to assist neoepitope targeting in personalized cancer immunotherapy

Annals of Oncology : Official Journal of the European Society for Medical Oncology
S K SainiS R Hadrup

Abstract

Current cancer immunotherapy approaches utilize the remarkable surveillance capacity of the human immune system, which is capable of recognizing and eliminating cancer cells based on identification of tumor-associated antigens arising as a consequence of the transformation process. Among these, mutational-derived neoepitopes have proved to be powerful targets for tumor elimination and mutational load has been shown to correlate with the clinical response to treatment with checkpoint inhibitors in many different tumor types. This suggests a crucial role for neoepitope recognition in T-cell-mediated tumor eradication. Consequently, strategies to further boost neoepitope recognition, through vaccination or adoptive cell transfer, has received substantial interest. Although such strategies have enormous potential, there are also considerable challenges associated with these approaches. In the present review, we will focus on how novel technological developments can facilitate and improve feasibility and efficacy in neoepitope targeting.

Citations

May 24, 2019·Journal for Immunotherapy of Cancer·Hanan BesserYoram Louzoun
Feb 14, 2019·Nature Reviews. Cancer·Jonathan J HavelTimothy A Chan
Jul 30, 2019·Journal of Cutaneous Medicine and Surgery·Arunima SivanandRobert Gniadecki
Sep 14, 2019·Nature Reviews. Genetics·Francesca FinotelloZlatko Trajanoski
Apr 18, 2018·Immunological Reviews·James L ReadingSergio A Quezada
Jun 30, 2018·Expert Opinion on Investigational Drugs·Michalis V Karamouzis, Athanasios G Papavassiliou
Jul 3, 2019·Biochimica Et Biophysica Acta. Reviews on Cancer·Maximilian BoeschMartin H Brutsche
Jul 14, 2020·Seminars in Cancer Biology·Ombretta MelaiuFederica Gemignani
Jul 22, 2019·Science Immunology·Sunil Kumar SainiSine Reker Hadrup
Dec 12, 2020·Current Opinion in Immunology·Muhammed A RahmanNaoto Hirano
Jul 2, 2021·Expert Review of Vaccines·Nasim EbrahimiMichael R Hamblin
Jul 2, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L De Mattos-ArrudaM Griffith
Aug 12, 2021·Nature Reviews. Cancer·Roman M ChabanonSophie Postel-Vinay

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Related Papers

Chinese Clinical Oncology
Anand PatelMary L Disis
Current Opinion in Oncology
S A Lynch, A N Houghton
Current Opinion in Immunology
Mathias VormehrUgur Sahin
© 2022 Meta ULC. All rights reserved