Novel Trajectories for Identifying Asthma Phenotypes: A Longitudinal Study in Korean Asthma Cohort, COREA

The Journal of Allergy and Clinical Immunology. in Practice
So Young ParkCOREA investigators

Abstract

Unbiased cluster analysis has identified several asthma phenotypes. However, these phenotypes did not consistently predict disease prognosis and reflect temporal variability in airway inflammation. We aimed to identify longitudinal trajectories in terms of pulmonary function parameters and investigated whether the trajectories are associated with prognosis. Data were extracted from the Cohort for Reality and Evolution of Adult Asthma in Korea (COREA). Three-year pulmonary function test results were used to apply finite mixture models for group-based trajectory in 486 patients with eligible data set. Two main sets of longitudinal trajectories were identified in terms of FEV1% predicted, and FEV1 variability. In the 4 trajectories determined with FEV1% predicted, the pulmonary function showed a consistent course in 4 stratified levels during 3 years of follow-up, which was associated with unexpected hospital visits and the use of steroid bursts due to exacerbation. The variability in pulmonary function showed 3 different patterns, and we found that higher blood and sputum eosinophil levels were associated with the higher variability in pulmonary function and more exacerbations. Trajectory analysis is a novel method that provides ...Continue Reading

Citations

Jul 15, 2020·Respiratory Research·Minna TommolaHannu Kankaanranta
Jul 30, 2020·American Journal of Respiratory and Critical Care Medicine·Chrysanthi Skevaki, Markus Weckmann
Nov 17, 2020·Allergy, Asthma & Immunology Research·Min Hye Kim, Tae Bum Kim
Nov 14, 2020·The Journal of Allergy and Clinical Immunology. in Practice·So-Young ParkUNKNOWN Cohort for Reality and Evolution of Adult Asthma in Korea (COREA) Study Group
May 1, 2021·Diagnostics·Francisco CunhaJoão A Fonseca
Apr 24, 2021·The Journal of Investigative Dermatology·Joslyn S Kirby
May 4, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Sae-Hoon KimUNKNOWN Cohort for Reality and Evolution of Adult Asthma (COREA) Study Group

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