Novel Treponema pallidum Recombinant Antigens for Syphilis Diagnostics: Current Status and Future Prospects

BioMed Research International
Aleksey KubanovDmitry Deryabin

Abstract

The recombinant protein technology considerably promoted the development of rapid and accurate treponema-specific laboratory diagnostics of syphilis infection. For the last ten years, the immunodominant recombinant inner membrane lipoproteins are proved to be sensitive and specific antigens for syphilis screening. However, the development of an enlarged T. pallidum antigen panel for diagnostics of early and late syphilis and differentiation of syphilis stages or cured syphilis remains as actual goal of multidisciplinary expertise. Current review revealed novel recombinant antigens: surface-exposed proteins, adhesins, and periplasmic and flagellar proteins, which are promising candidates for the improved syphilis serological diagnostics. The opportunities and limitations of diagnostic usage of these antigens are discussed and the criteria for selection of optimal antigens panel summarized.

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Citations

Apr 3, 2019·Journal of Clinical Laboratory Analysis·Chenglong ZhouFeijun Zhao
Jan 1, 2019·Journal of Cellular and Molecular Medicine·Xi LuoFeijun Zhao
Jun 22, 2018·PLoS Neglected Tropical Diseases·Verena J SchuenemannJohannes Krause

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Methods Mentioned

BETA
electrophoretic techniques
electrophoresis
PCR
enzyme-linked immunosorbent assay
ELISA

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