Novel triple-reassortant influenza viruses in pigs, Guangxi, China

Emerging Microbes & Infections
Ping HeYing Chen

Abstract

Considered a "mixing vessel" for influenza viruses, pigs can give rise to new influenza virus reassortants that can threaten humans. During our surveillance of pigs in Guangxi, China from 2013 to 2015, we isolated 11 H1N1 and three H3N2 influenza A viruses of swine origin (IAVs-S). Out of the 14, we detected ten novel triple-reassortant viruses, which contained surface genes (hemagglutinin and neuraminidase) from Eurasian avian-like (EA) H1N1 or seasonal human-like H3N2, matrix (M) genes from H1N1/2009 pandemic or EA H1N1, nonstructural (NS) genes from classical swine, and the remaining genes from H1N1/2009 pandemic. Mouse studies indicate that these IAVs-S replicate efficiently without prior adaptation, with some isolates demonstrating lethality. Notably, the reassortant EA H1N1 viruses with EA-like M gene have been reported in human infections. Further investigations will help to assess the potential risk of these novel triple-reassortant viruses to humans.

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Citations

Sep 20, 2019·Transboundary and Emerging Diseases·Zhijun YuJiaqiang Wu
Jul 10, 2019·Emerging Microbes & Infections·Guojun WangAdolfo García-Sastre
Jul 1, 2020·Proceedings of the National Academy of Sciences of the United States of America·Honglei SunJinhua Liu
Aug 10, 2021·Frontiers in Public Health·Beatriz Delgado-HernándezPastor Alfonso

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Datasets Mentioned

BETA
KM061010
KM061025
MF927789
MF927884

Methods Mentioned

BETA
glycosylation

Software Mentioned

DNASTAR
Megalign
Seqman
MEGA

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