Novel tubular constructs for urinary diversion: a biocompatibility study in pigs

Journal of Tissue Engineering and Regenerative Medicine
Marije SloffWout F Feitz

Abstract

The use of bowel tissue for urinary diversion can be associated with severe complications, and regenerative medicine may circumvent this by providing an engineered conduit. In this study, a novel tubular construct was identified for this purpose. Three constructs (diameter 15 mm) were prepared from type I collagen and either (a) a semi-biodegradable Vypro II polymer (COL-Vypro), (b) a rapidly biodegradable Vicryl polymer (COL-Vicryl) or (c) an additional collagenous layer (COL-DUAL). After freezing, lyophilization and crosslinking, all constructs showed a porous structure with a two-fold higher strength for the polymer-containing constructs. These constructs were connected to full bladder defects of 11 female pigs and evaluated after 1 (n = 4) or 3 months (n = 5). With respect to surgical handling, the polymer-containing constructs were superior. All pigs voided normally without leakage and the survival rate was 82%. For the implanted COL-Vypro constructs (8/9), stone formation was observed. COL-DUAL and COL-Vicryl showed better biocompatibility and only small remnants were found 1 month post-implantation. Histological and immunohistochemical analysis showed the best regeneration for COL-Vicryl with respect to urothelium; muscl...Continue Reading

References

Apr 1, 1996·Biomaterials·L H Olde DaminkJ Feijen
Mar 31, 1998·Urologia Internationalis·J Pannek, T Senge
May 1, 1998·Pediatric Surgery International·D ShinharA J Mares
Feb 11, 2003·The Journal of Urology·Stephen MadersbacherUrs E Studer
Nov 19, 2003·Advanced Drug Delivery Reviews·Donald G Wallace, Joel Rosenblatt
Oct 1, 1950·The Surgical Clinics of North America·E M BRICKER
Aug 19, 2004·World Journal of Urology·Scott B Farnham, Michael S Cookson
Sep 20, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Loïc BoulangerMichel Cosson
Jun 21, 2007·Transplantation Proceedings·T Drewa
Mar 20, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tom P V M de JongPieter Dik
Oct 12, 2010·Tissue Engineering. Part C, Methods·Martin J W KoensToin H van Kuppevelt
Jul 30, 2011·Prehospital Emergency Care : Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors·UNKNOWN National Association of EMS Physicians
Nov 3, 2011·Nature Reviews. Urology·Richard E HautmannOliver Hautmann
Dec 6, 2011·Tissue Engineering. Part a·Joydeep BasuJohn W Ludlow
Jun 19, 2012·The Journal of Urology·Paul GeutjesWout Feitz
Nov 13, 2012·The Journal of Surgical Research·Wenbiao LiaoYunhe Xiong
Mar 20, 2013·Neurourology and Urodynamics·Vatche A MinassianLouise Litzy
Apr 29, 2014·The Journal of Urology·Marije SloffWout Feitz
May 21, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Katrien M BrouwerToin H van Kuppevelt
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray

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Citations

May 18, 2016·The Journal of Urology·Marije SloffWout F J Feitz
Mar 23, 2017·Tissue Engineering. Part a·Luc A J RoelofsWout F J Feitz
Dec 28, 2018·Expert Review of Medical Devices·Jan AdamowiczTomasz Drewa
Feb 23, 2019·Tissue Engineering. Part B, Reviews·Heinz P JankeEgbert Oosterwijk
Dec 7, 2018·BioMed Research International·Iwona Otrocka-DomagałaTomasz Maślanka
Sep 18, 2018·ACS Biomaterials Science & Engineering·Marije SloffEgbert Oosterwijk

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