Novel use of XSTAT 30 for mitigation of lethal non-compressible torso hemorrhage in swine

PloS One
Alicia M BonannoJames D Ross

Abstract

Management of Non-Compressible Torso Hemorrhage (NCTH) consists primarily of aortic occlusion which has significant adverse outcomes, including ischemia-reperfusion injury, in prolonged field care paradigms. One promising avenue for treatment is through use of RevMedx XSTAT 30™ (an FDA approved sponge-based dressing utilized for extremity wounds). We hypothesized that XSTAT 30™ would effectively mitigate NCTH during a prolonged pre-hospital period with correctable metabolic and physiologic derangements. Twenty-four male swine (53±2kg) were anesthetized, underwent line placement, and splenectomy. Animals then underwent laparoscopic transection of 70% of the left lobe of the liver with hemorrhage for a period of 10min. They were randomized into three groups: No intevention (CON), XSTAT 30™-Free Pellets (FP), and XSTAT 30™-Bagged Pellets (BP). Animals were observed for a pre-hospital period of 180min. At 180min, animals underwent damage control surgery (DCS), balanced blood product resuscitation and removal of pellets followed by an ICU period of 5 hours. Postoperative fluoroscopy was performed to identify remaining pellets or bags. Baseline physiologic and injury characteristics were similar. Survival rates were significantly hig...Continue Reading

References

Aug 4, 2011·The Journal of Trauma·Brian J EastridgeLorne H Blackbourne
Aug 2, 2013·The Journal of Trauma and Acute Care Surgery·Jason M RallJames D Ross
May 20, 2014·The Journal of Surgical Research·Jonathan J MorrisonTodd E Rasmussen
Jul 25, 2014·The Journal of Trauma and Acute Care Surgery·James S DavisCarl I Schulman
Aug 28, 2014·The Journal of Trauma and Acute Care Surgery·Adam P RagoDavid R King
Aug 28, 2014·The Journal of Trauma and Acute Care Surgery·James D RossJonathan J Morrison
May 3, 2015·The American Journal of Emergency Medicine·John F KraghMichael A Dubick
Aug 18, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Oktay KarakoseIbrahim Barut
Sep 28, 2017·Current Opinion in Critical Care·Philbert Y VanMartin A Schreiber
Oct 11, 2017·The Journal of Trauma and Acute Care Surgery·Anders J DavidsonUNKNOWN BEST Study Group
Dec 22, 2017·The Journal of Trauma and Acute Care Surgery·Anders J DavidsonUNKNOWN BEST Study Group

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
sedation

Software Mentioned

SigmaPlot
XSTAT
SyStat
REBOA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The American Journal of Emergency Medicine
John F KraghMichael A Dubick
Journal of Special Operations Medicine : a Peer Reviewed Journal for SOF Medical Professionals
Jennifer M Cox, Jason M Rall
The Journal of Trauma and Acute Care Surgery
James D RossJonathan J Morrison
Critical Care Clinics
Jonathan J Morrison
© 2021 Meta ULC. All rights reserved