PMID: 12759436May 22, 2003Paper

Novel variants of the IL-10 receptor 1 affect inhibition of monocyte TNF-alpha production

The Journal of Immunology : Official Journal of the American Association of Immunologists
Christoph GascheA Gangl

Abstract

IL-10-deficient mice exhibit spontaneous enterocolitis and other symptoms akin to Crohn's disease, indicating that IL-10 might regulate normal physiology in the gut. However, clinical trials with IL-10 in Crohn's disease were disappointing, although some patients showed healing of intestinal mucosa. This study searched for genetic polymorphisms within the IL-10 pathway. We decided to screen for mutations of the IL-10R1 cDNA in healthy volunteers and Crohn's disease patients and identified two novel variants: a serine 138-to-glycine (S138G) and a glycine 330-to-arginine (G330R) substitution. The allelic frequency in a European cohort was relatively high (16% for the S138G and 33% for the G330R), and S138G was in strong linkage disequilibrium with G330R. A similar allele frequency was found in a group of Crohn's patients. In IL-10R1 G330R-expressing monocytes, the inhibitory effect of IL-10 on TNF-alpha production was diminished, indicating that this variant may be a loss-of-function allele. No such difference was observed between haplotypes 4 (G330R only) and 7 (S138G and G330R). In addition, these IL-10R1 variants had no influence on the IL-10R1 expression density. Structural analysis of the S138G variant revealed that the subs...Continue Reading

References

Mar 1, 1991·Acta Crystallographica. Section A, Foundations of Crystallography·T A JonesM Kjeldgaard
Sep 1, 1995·Molecular and Cellular Biology·A S HoK W Moore
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A S HoK W Moore
Oct 1, 1996·Protein Science : a Publication of the Protein Society·A ZdanovA Wlodawer
Apr 1, 1997·Journal of Leukocyte Biology·D M RennickN J Davidson
Sep 12, 1997·Science·J E Darnell
Mar 28, 1998·The Journal of Experimental Medicine·S D SpencerM Aguet
Jul 17, 1998·The American Journal of Pathology·F AutschbachS C Meuer
Aug 11, 1998·Clinical and Experimental Immunology·M ParkesD Jewell
Aug 5, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·R P DonnellyD S Finbloom
Nov 7, 1999·Tissue Antigens·A TagoreI V Hutchinson
Oct 29, 2000·Journal of Clinical Immunology·C GascheW Reinisch
Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
Mar 5, 2002·Nature Medicine·Tzong-Shyuan Lee, Lee-Young Chau
May 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Agnes DenysBrian M J Foxwell

❮ Previous
Next ❯

Citations

Oct 27, 2004·Immunology·Lynn M WilliamsBrian M J Foxwell
Nov 20, 2008·European Journal of Immunology·Sabine G GruberChristoph Gasche
Jul 31, 2009·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Chris P VerschoorNiel A Karrow
Jun 10, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Efe SezginUNKNOWN SOCA Research Group
May 28, 2013·Clinical Rheumatology·Hui PengDong-Qing Ye
Sep 22, 2009·Journal of Biomedical Materials Research. Part a·Ryan G SoderquistMelissa J Mahoney
Sep 16, 2010·Inflammatory Bowel Diseases·Christoph GascheAbdelaziz Sefiani
Aug 11, 2015·AIDS Patient Care and STDs·Nazli DemirkayaFranciscus Verbraak
Feb 23, 2017·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Nadia Ben FredjMahjoub Aouni
Sep 19, 2008·Genes and Immunity·P GrundtnerC Gasche
May 13, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Sherry H-Y WeiAlice L-F Mui
Oct 27, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Alexandra SchosserChristoph Gasche
Jun 3, 2011·European Journal of Clinical Investigation·Gregor PaulChristoph Gasche
Sep 11, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kushi KushekharArjan Diepstra
Dec 1, 2010·Cytokine & Growth Factor Reviews·Robert SabatJens Geginat

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.