PMID: 11920826Mar 29, 2002Paper

Novel variants related to TT virus distributed widely in China

Journal of Medical Virology
Kangxian LuoLian Zhang

Abstract

TTV is a DNA virus with high genetic heterogeneity. To investigate the novel isolates of the virus, blood samples were collected from subjects who lived in various parts of China and suffered from hepatitis or were asymptomatic carriers. Nested PCR was carried out to amplify a 3.2-kb fragment using primers deduced from the prototype TTV (TA278). The ten entire 3.2-kb nt sequences were aligned with isolate TA278, SANBAN, TUS01, and SENV retrieved from GenBank, and a phylogenetic tree was constructed by Neighbor-Joining method. The analysis indicated that five novel variants of the present study have not been described before, and all TTV-related isolates could be classified into three groups. The isolate TCHN-A, B and TUS01 were included in a group, and the remaining novel isolates together with SANBAN and TA278 clustered into another group, while SEN virus formed a distinct group. The genetic distances of the five novel variants were 0.5507-0.8476 to TA278, 0.4635-0.7877 to SANBAN, 0.6064-0.7834 to TUS01 and 0.6936-0.8236 to SENV. Of these novel variants, the ORF1 consisted of 426-772 aa and ORF2 of 141-156 aa. The nt identities of ORF1 and ORF2 between those variants and TA278, SANBAN, and TUS01 were 46.1-60.8 and 48.7-63.6%, ...Continue Reading

References

Feb 12, 1998·Biochemical and Biophysical Research Communications·T NishizawaM Mayumi
May 2, 1998·European Journal of Gastroenterology & Hepatology·S P Wilkinson
Mar 6, 1999·Biochemical and Biophysical Research Communications·S TakayamaS Sugii
Mar 12, 1999·The Journal of General Virology·P BiaginiX de Lamballerie
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·I K MushahwarS M Dexai
Oct 9, 1999·The Journal of Infectious Diseases·K ItohH Okamoto
Mar 9, 2000·Journal of Virology·Y E KhudyakovH A Fields
May 18, 2000·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·P GallianX de Lamballerie
Jun 10, 2000·Journal of Viral Hepatitis·K X LuoQ Lu
Aug 22, 2000·The Journal of General Virology·R L HallettC G Teo

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Citations

Jun 29, 2007·Journal of Virology·Ludmila LeppikEthel-Michele de Villiers
Oct 7, 2008·Virology Journal·Jennifer S GriffinSharon C Long
Jul 9, 2004·Genetics·Wendy S W Wong, Rasmus Nielsen
Dec 2, 2015·Biomedical Reports·Youping WeiLianping Li
Sep 19, 2008·Virology·Bettina MuellerAnnette Mankertz
Feb 15, 2015·Archives of Virology·Sonia SpandoleGrigore Mihăescu
Aug 12, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Florencia CancelaJuan Arbiza
Dec 21, 2006·Journal of Medical Virology·Moslih I Al-MoslihYu-Wen Hu
Apr 11, 2003·Current Opinion in Infectious Diseases·C Anthony Hart, Nicholas J Beeching
Aug 13, 2021·Archives of Virology·Arvind VarsaniSimona Kraberger

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