Novelty modulates human striatal activation and prefrontal-striatal effective connectivity during working memory encoding

Brain Structure & Function
Lena S GeigerHeike Tost

Abstract

The functional role of the basal ganglia (BG) in the gating of suitable motor responses to the cortex is well established. Growing evidence supports an analogous role of the BG during working memory encoding, a task phase in which the "input-gating" of relevant materials (or filtering of irrelevant information) is an important mechanism supporting cognitive capacity and the updating of working memory buffers. One important aspect of stimulus relevance is the novelty of working memory items, a quality that is understudied with respect to its effects on corticostriatal function and connectivity. To this end, we used functional magnetic resonance imaging (fMRI) in 74 healthy volunteers performing an established Sternberg working memory task with different task phases (encoding vs. retrieval) and degrees of stimulus familiarity (novel vs. previously trained). Activation analyses demonstrated a highly significant engagement of the anterior striatum, in particular during the encoding of novel working memory items. Dynamic causal modeling (DCM) of corticostriatal circuit connectivity identified a selective positive modulatory influence of novelty encoding on the connection from the dorsolateral prefrontal cortex (DLPFC) to the anterio...Continue Reading

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Citations

Mar 25, 2019·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Jeong Ha ParkDoug Hyun Han
Jun 4, 2021·Frontiers in Human Neuroscience·Ingo HertrichHermann Ackermann
Jul 22, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jason SmucnyCameron S Carter

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Methods Mentioned

BETA
SMA

Software Mentioned

DCM
DCM12
Statistical Parametric Mapping SPM8
SPM12
SPM8

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