Nox4 oxidase overexpression specifically decreases endogenous Nox4 mRNA and inhibits angiotensin II-induced adventitial myofibroblast migration.

Mounir J HauraniPatrick J Pagano


The vascular adventitia is emerging as an important modulator of vessel remodeling. Adventitial myofibroblasts migrate to the neointima after balloon angioplasty, contributing to restenosis. We postulated that angiotensin II (Ang II) enhances adventitial myofibroblast migration in vitro via reduced nicotinamide-adenine dinucleotide phosphate oxidase-derived H(2)O(2) and that Nox4-based oxidase promotes migration. Ang II increased myofibroblast migration in a concentration-dependent manner, with a peak increase of 1023+/-83%. Rat adventitial myofibroblasts were cotransfected with human Nox4 and human p22-phox plasmids or an empty vector. PCR showed an 8-fold increase in human Nox4 and human p22-phox plasmid expression. Using RT-PCR with primers specifically designed for rat reduced nicotinamide-adenine dinucleotide phosphate oxidases, endogenous Nox levels were determined. Ang II decreased endogenous Nox4 and Nox1 mRNA to 41% and 27% of control, respectively, but had no effect on Nox2. Cotransfection with human Nox4 and human p22-phox plasmids combined with Ang II reduced endogenous Nox4 mRNA levels (37+/-5% of control; P<0.05), whereas it had no significant effect on Nox1 or Nox2. In empty vector-transfected cells, Ang II incre...Continue Reading


Aug 7, 1993·Journal of Theoretical Biology·N C Kyrpides, C A Ouzounis
Dec 1, 1996·Journal of Leukocyte Biology·F R DeLeo, M T Quinn
Mar 14, 1997·Science·K IraniP J Goldschmidt-Clermont
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·P J PaganoM T Quinn
Mar 24, 1998·Annual Review of Medicine·S M Schwartz, C E Murry
Jun 28, 2000·Proceedings of the National Academy of Sciences of the United States of America·M GeisztT L Leto
Oct 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·M E CifuentesP J Pagano
Mar 27, 2002·Circulation·Dan SorescuKathy K Griendling
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