Noxious inputs to supraoptic neurosecretory cells in the rat

Neuroscience Research
M HamamuraK Yagi

Abstract

The effects of noxious stimuli were studied on discharge activity of the neurosecretory cells identified in the supraoptic nucleus by antidromic excitation after pituitary stimulation, in anaesthetized rats. Tail pinching excited 24% and inhibited spontaneous discharge of 6% of the 91 cells tested. Noxious heat stimuli (44-63 degrees C) applied to the hindlimb paw produced a transient excitation in 26% of the 23 cells tested. Electric stimulation of either the sciatic or cutaneous nerve with 20-Hz pulses for 1 s, at an intensity 5 times stronger than the threshold for evoking the changes in respiratory movements and blood pressure similar to those after tail pinching or noxious heat stimuli, excited about 30% of the cells tested. The excitation produced by these noxious stimuli preceded, on some occasions, the respiratory movement and blood pressure decrease which occurred concomitantly. Peristimulus time histograms of spontaneous discharges constructed during stimulation of either nerve at 1 Hz, revealed the presence of excitatory synaptic inputs in about 35% of the neurosecretory cells tested. These data indicate the existence of direct neural pathways which mediate excitatory synaptic inputs originating from nociceptors to s...Continue Reading

References

Apr 1, 1977·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D A PoulainR E Dyball
May 1, 1976·The Journal of Physiology·J J DreifussE Tribollet
Nov 6, 1975·Nature·J B WakerleyB A Cross

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Citations

Dec 1, 1988·Neuroscience Research·T Onaka, K Yagi
Mar 4, 2000·Journal of the Autonomic Nervous System·S IdeguchiM Umino
May 30, 2002·Progress in Neurobiology·Mark J Millan
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·H KannanC M Brooks
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S CeccatelliT Hökfelt
Jul 5, 2005·Brain Research·Maria Zubrzycka, Anna Janecka
Aug 31, 2019·Cephalalgia : an International Journal of Headache·Arne May, Rami Burstein
Jan 11, 1991·The Journal of Comparative Neurology·J T KatterG J Giesler
Jul 25, 1992·The Journal of Comparative Neurology·K IwataR L Nahin
Jan 15, 1990·The Journal of Comparative Neurology·R BursteinG J Giesler

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