ΔNp63 regulates the expression of hyaluronic acid-related genes in breast cancer cells

Oncogenesis
Veronica GattiAngelo Peschiaroli

Abstract

Triple negative breast cancers (TNBC) represent the most aggressive and clinically relevant breast carcinomas. On the basis of specific molecular signature, the majority of TNBC can be classified as basal-like breast carcinoma. Here, we report data showing that in basal-like breast carcinoma cells ΔNp63 is capable of sustaining the production of the hyaluronic acid (HA), one of the major component of the extracellular matrix (ECM). At molecular level, we found that ΔNp63 regulates the expression of HA-related genes, such as the HA synthase HAS3, the hyaluronidase HYAL-1 and CD44, the major HA cell membrane receptor. By controlling this pathway, ∆Np63 contributes to maintain the self-renewal of breast cancer stem cells. Importantly, high HAS3 expression is a negative prognostic factor of TNBC patients. Our data suggest that in basal-type breast carcinoma ∆Np63 might favor a HA-rich microenviroment, which can sustain tumor proliferation and stemness.

References

Aug 24, 1999·The Journal of Biological Chemistry·N ItanoK Kimata
Feb 24, 2001·Annals of the New York Academy of Sciences·V De Laurenzi, G Melino
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·A Yang, F McKeon
Jan 4, 2003·Nature Reviews. Molecular Cell Biology·Helmut PontaPeter A Herrlich
Oct 21, 2003·International Journal of Cancer. Journal International Du Cancer·Kelli M BullardJames B McCarthy
Dec 6, 2003·Journal of Cell Science·Christina FieberJonathan P Sleeman
Jun 11, 2004·The Journal of Biological Chemistry·Ikuko KakizakiNaoki Itano
Jul 2, 2004·Nature Reviews. Cancer·Bryan P Toole
Oct 27, 2004·European Journal of Cell Biology·Robert Stern
Jan 6, 2005·The Journal of Biological Chemistry·Shibnath GhatakBryan P Toole
May 14, 2005·Matrix Biology : Journal of the International Society for Matrix Biology·Luigi RaioPierfrancesco Bolis
Mar 9, 2006·Chemical Reviews·Robert Stern, Mark J Jedrzejas
May 23, 2006·Nature Cell Biology·Danielle K CarrollLeif W Ellisen
Nov 10, 2006·Journal of Cell Science·Eleonora CandiGerry Melino
Feb 14, 2007·Cell Cycle·Barry TrinkDavid Sidransky
May 16, 2007·The Journal of Biological Chemistry·Alamelu G BharadwajMelanie A Simpson
May 10, 2008·Seminars in Cancer Biology·David NaorRonit Vogt Sionov
Sep 30, 2010·Nature Reviews. Clinical Oncology·Lisa CareyLuca Gianni
Oct 19, 2010·Biochemical and Biophysical Research Communications·Angelo PeschiaroliGerry Melino
Nov 12, 2010·The New England Journal of Medicine·William D FoulkesJorge S Reis-Filho
Mar 3, 2011·The FEBS Journal·Vincent Hascall, Nikos Karamanos
Mar 24, 2011·Nature Reviews. Molecular Cell Biology·Arnold J LevineGerry Melino
Jul 16, 2011·Cell Death and Differentiation·G Melino
Jul 23, 2011·Genes & Cancer·Alessandro RufiniRichard A Knight
Sep 25, 2012·Nature·UNKNOWN Cancer Genome Atlas Network
Sep 29, 2012·Genes & Development·Corrie L Gallant-BehmJoaquín M Espinosa
Jan 1, 2012·Oncogenesis·M T BranhamM Roqué
Apr 12, 2013·Cell Cycle·Arianna GiacobbeAngelo Peschiaroli
Aug 8, 2013·Journal of Proteome Research·Angelo D'AlessandroLello Zolla
Sep 24, 2013·Histochemistry and Cell Biology·Kari TörrönenKirsi Rilla
Feb 12, 2014·Biochimica Et Biophysica Acta·Davide VigettiAlberto Passi
Mar 7, 2014·Journal of Proteome Research·Simona D'AguannoVincenzo De Laurenzi

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Citations

May 28, 2019·European Radiology·Gisela L G MenezesRuud M Pijnappel
Sep 13, 2020·Journal of Cell Science·Matthew L FisherAlea A Mills
Jun 5, 2019·International Journal of Molecular Sciences·Veronica GattiAngelo Peschiaroli
Jun 21, 2020·Cancers·Veronica GattiAngelo Peschiaroli
Jul 31, 2019·Cellular Signalling·Spyros S SkandalisNikos K Karamanos
Dec 30, 2020·Cancers·Flavia Fico, Albert Santamaria-Martínez
Oct 12, 2021·European Journal of Human Genetics : EJHG·Julia SchmidtBernd Wollnik

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Methods Mentioned

BETA
PCR
transfection
Enzyme-Linked Immunosorbent Assay
ELISA
ChIP-seq

Software Mentioned

matlab

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