Abstract
Caveolins have recently attracted attention for their possible involvement in signal transduction. Their role in cancer is debated, being reported both a suppressive and oncogenic role in different experimental conditions. Caveolin-1 is regulated by the tumor suppressor p53 which is able to bind its promoter and activate transcription. We had previous evidences indicating that a specific p73 isoform, namely ∆Np73β, when overexpressed in NCI-H1299 induced growth arrest and cell death. By gene expression analysis in cell transiently overexpressed with ∆Np73β, a strong induction of caveolin-1 was found. Caveolin was induced both at mRNA and protein level, and we characterised the promoter sequence of the gene encoding for caveolin-1 and found that the promoter region containing the putative p53 (and hence p73) binding sequence was responsive to ∆Np73β, but not to ∆Np73α and ∆Np73γ which do not induce growth arrest as ∆Np73β does. A reduction in cell adhesion was observed in ∆Np73β overexpressing cells, again supporting a possible role of caveolins in determining these effects. By using specific siRNA directed against human caveolin-1, we could not however antagonize the effects induced by ∆Np73β. Although caveolin-1 represents one...Continue Reading
References
Jul 3, 1997·International Journal of Cancer. Journal International Du Cancer·F VikhanskayaP Russo
Nov 21, 1998·The EMBO Journal·F GalbiatiM P Lisanti
Nov 5, 2002·The American Journal of Pathology·Chao-Chi HoSu-Ming Hsu
Mar 17, 2007·Cancer Research·Michelle I LinWilliam C Sessa
Apr 13, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Mirko MarabeseMassimo Broggini
Aug 19, 2007·Cancer Research·Lara CantianiKatia Scotlandi
Feb 9, 2008·Cell Death and Differentiation·M MarabeseM Broggini
Nov 13, 2008·British Journal of Cancer·H ZhangZ G Chen
Nov 15, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E MarrazzoM Broggini
Mar 24, 2009·The FEBS Journal·Xin YuArnold J Levine
Mar 6, 2010·Cardiovascular Research·John H Chidlow, William C Sessa
May 31, 2011·Cancer Research·Wen-Tai ChiuSuyun Huang
Nov 2, 2011·Cell Cycle·Ahmed F SalemMichael P Lisanti
Jan 27, 2012·American Journal of Physiology. Cell Physiology·Preedakorn ChunhachaPithi Chanvorachote
Mar 13, 2012·Cellular Signalling·Fabia PancottiAnna Gasperi-Campani
Apr 20, 2013·Cell Cycle·Kevin QuannJean-François Jasmin
Jan 29, 2014·Current Molecular Medicine·S Núñez-WehingerA F G Quest
Mar 8, 2014·Molecular Medicine Reports·Rui WangTao Huang
May 27, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Heidi N FridolfssonHemal H Patel
Aug 3, 2014·Carcinogenesis·Zhiyu WangJianping Chen
Sep 16, 2014·PloS One·Seth A BrodieJohann C Brandes