∆Np73beta induces caveolin-1 in human non-small cell lung cancer cell line H1299

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Elisa CaiolaMirko Marabese

Abstract

Caveolins have recently attracted attention for their possible involvement in signal transduction. Their role in cancer is debated, being reported both a suppressive and oncogenic role in different experimental conditions. Caveolin-1 is regulated by the tumor suppressor p53 which is able to bind its promoter and activate transcription. We had previous evidences indicating that a specific p73 isoform, namely ∆Np73β, when overexpressed in NCI-H1299 induced growth arrest and cell death. By gene expression analysis in cell transiently overexpressed with ∆Np73β, a strong induction of caveolin-1 was found. Caveolin was induced both at mRNA and protein level, and we characterised the promoter sequence of the gene encoding for caveolin-1 and found that the promoter region containing the putative p53 (and hence p73) binding sequence was responsive to ∆Np73β, but not to ∆Np73α and ∆Np73γ which do not induce growth arrest as ∆Np73β does. A reduction in cell adhesion was observed in ∆Np73β overexpressing cells, again supporting a possible role of caveolins in determining these effects. By using specific siRNA directed against human caveolin-1, we could not however antagonize the effects induced by ∆Np73β. Although caveolin-1 represents one...Continue Reading

References

Jul 3, 1997·International Journal of Cancer. Journal International Du Cancer·F VikhanskayaP Russo
Apr 13, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Mirko MarabeseMassimo Broggini
Feb 9, 2008·Cell Death and Differentiation·M MarabeseM Broggini
Nov 15, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E MarrazzoM Broggini
Mar 24, 2009·The FEBS Journal·Xin YuArnold J Levine
Mar 6, 2010·Cardiovascular Research·John H Chidlow, William C Sessa
Jan 27, 2012·American Journal of Physiology. Cell Physiology·Preedakorn ChunhachaPithi Chanvorachote
Jan 29, 2014·Current Molecular Medicine·S Núñez-WehingerA F G Quest
May 27, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Heidi N FridolfssonHemal H Patel

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Citations

Nov 10, 2016·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Fariba BineshZahra Kargar Hadgiabadi

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