Nphe1]nociceptin(1-13)-NH2 antagonizes nociceptin-induced hypotension, bradycardia, and hindquarters vasodilation in the anesthetized rat

Canadian Journal of Physiology and Pharmacology
Y ChenR Wang

Abstract

The purpose of this study was to investigate the effects of [Nphe1]nociceptin(1-13)-NH2 on nociceptin-induced decreases in mean arterial pressure (MAP), heart rate (HR), and hindquarters vascular bed resistance (HVBR) of the anesthetized rat. The results showed that i.c.v. or i.v. [Nphe1]nociceptin(1-13)-NH2 (1.5-12 nmol/kg and 5-120 nmol/kg, respectively) could antagonize the depressor effects of i.c.v. or i.v. nociceptin (3 and 30 nmol/kg, respectively) on MAP and HR. Furthermore, [Nphe1]nociceptin(1-13)-NH2 (5-120 nmol/kg) could reverse nociceptin (30 nmol/kg)-induced decrease of HVBR. However, [Nphe1]nociceptin(1-13)-NH2 had no significant effects on similar effects induced by morphine. Our results suggest that [Nphe1]nociceptin(1-13)-NH2 acts as a selective antagonist of the nociceptin receptor in the cardiovascular system of the rat.

References

Aug 27, 1997·European Journal of Pharmacology·S GiulianiC A Maggi
Nov 19, 1997·Neuroscience Letters·N J DunL L Hwang

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Citations

Nov 13, 2003·Peptides·Richard J Bodnar, Maria M Hadjimarkou
Nov 26, 2002·European Journal of Pharmacology·Aly M Abdelrahman, Catherine C Y Pang
May 29, 2013·Pharmacology & Therapeutics·Elaine Cristina Gavioli, Girolamo Calo'
Jul 12, 2005·CNS Drug Reviews·Girolamo CaloDomenico Regoli
Apr 25, 2007·The Journal of Pharmacology and Experimental Therapeutics·Melissa A Burmeister, Daniel R Kapusta
Jun 10, 2008·The Journal of Pharmacology and Experimental Therapeutics·Melissa A BurmeisterDaniel R Kapusta

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