NPY Y2 receptor agonist PYY(3-36) inhibits diarrhea by reducing intestinal fluid secretion and slowing colonic transit in mice

Peptides
Ryuichi MoriyaAkio Kanatani

Abstract

Peptide YY (PYY)(3-36), a neuropeptide Y (NPY) Y2 receptor agonist, is a powerful inhibitor of intestinal secretion. Based on this anti-secretory effect, NPY Y2 receptor agonists may be useful as novel anti-diarrheal agents, but anti-diarrheal efficacy has yet to be determined. We therefore examined the anti-diarrheal efficacy of PYY(3-36) and a selective Y2 receptor agonist, N-acetyl-[Leu28, Leu31]-NPY(24-36), in experimental mouse models of diarrhea. Intraperitoneal administration of PYY(3-36) (0.01-1mg/kg) and N-acetyl-[Leu28, Leu31]-NPY(24-36) (10mg/kg) significantly inhibited diarrhea (increase in wet fecal weight and diarrhea score) induced by dimethyl-prostaglandin E2, 5-hydroxytryptamine, and castor oil. Anti-diarrheal activities of PYY(3-36) and N-acetyl-[Leu28, Leu31]-NPY(24-36) were comparable to the effects of loperamide (1mg/kg), a widely used anti-diarrheal drug. To clarify the anti-diarrheal mechanisms of NPY Y2 receptor agonists, we investigated the effects of PYY(3-36) and N-acetyl-[Leu28, Leu31]-NPY(24-36) on intestinal fluid secretion and colonic transit. PYY(3-36) (1mg/kg) and N-acetyl-[Leu28, Leu31]-NPY(24-36) (10mg/kg) significantly reduced dimethyl-prostaglandin E2-induced intestinal fluid accumulation in...Continue Reading

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Citations

Oct 18, 2011·Digestive Diseases and Sciences·Michael CamilleriTyler Nelsen
Jun 10, 2010·Current Gastroenterology Reports·Christina M Surawicz
Mar 8, 2014·World Journal of Gastroenterology : WJG·Magdy El-SalhyTrygve Hausken
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Nov 13, 2015·PloS One·Kristian H MikkelsenFilip K Knop
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May 23, 2013·International Journal of Molecular Medicine·Magdy El-SalhyTrygve Hausken
Mar 7, 2019·Frontiers in Endocrinology·Mihai CovasaClaudiu Cobuz
Jun 21, 2021·Archives of Toxicology·M Carmen LouzaoLuis M Botana
Mar 25, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rui XiongChangjiang Hu

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