PMID: 9448300Mar 14, 1998Paper

Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport

Proceedings of the National Academy of Sciences of the United States of America
M D FlemingN C Andrews

Abstract

The Belgrade (b) rat has an autosomal recessively inherited, microcytic, hypochromic anemia associated with abnormal reticulocyte iron uptake and gastrointestinal iron absorption. The b reticulocyte defect appears to be failure of iron transport out of endosomes within the transferrin cycle. Aspects of this phenotype are similar to those reported for the microcytic anemia (mk) mutation in the mouse. Recently, mk has been attributed to a missense mutation in the gene encoding the putative iron transporter protein Nramp2. To investigate the possibility that Nramp2 was also mutated in the b rat, we established linkage of the phenotype to the centromeric portion of rat chromosome 7. This region exhibits synteny to the chromosomal location of Nramp2 in the mouse. A polymorphism within the rat Nramp2 gene cosegregated with the b phenotype. A glycine-to-arginine missense mutation (G185R) was present in the b Nramp2 gene, but not in the normal allele. Strikingly, this amino acid alteration is the same as that seen in the mk mouse. Functional studies of the protein encoded by the b allele of rat Nramp2 demonstrated that the mutation disrupted iron transport. These results confirm the hypothesis that Nramp2 is the protein defective in th...Continue Reading

References

Apr 1, 1988·British Journal of Haematology·A Egyed
Jul 1, 1970·Transplantation·R J GraffS G Nathenson
Oct 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·J A Edwards, J E Hoke
Nov 20, 1969·Annals of the New York Academy of Sciences·D Sladic-SimicH M Ranney
May 1, 1981·The Journal of Pediatrics·G R Buchanan, R G Sheehan
Feb 1, 1995·Journal of Cellular Physiology·L L HodgsonE H Morgan
Jan 1, 1993·Mammalian Genome : Official Journal of the International Mammalian Genome Society·K F Manly
Apr 1, 1996·American Journal of Hematology·K R Hartman, J A Barker
Apr 1, 1997·Nature Medicine·R G Crystal
Apr 1, 1997·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·M GarrickL Garrick
Aug 1, 1997·Nature Genetics·J V Gray, K J Johnson
Jul 1, 1997·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·A C Chua, E H Morgan

❮ Previous
Next ❯

Citations

Aug 27, 1999·Journal of Cellular Biochemistry·M LusićZ Popović
Feb 16, 1999·Journal of Cellular Physiology·L M GarrickM D Garrick
Feb 13, 2001·Journal of Cellular Physiology·E H Morgan
Jul 12, 2002·Annals of Neurology·Holly A ZywickeJeff W M Bulte
Apr 5, 2002·Journal of Neuroscience Research·Jerome A RothMichael D Garrick
Apr 5, 2002·Medicinal Research Reviews·Hongyan Li, Zhong Ming Qian
Sep 26, 2008·European Journal of Nutrition·Nathalie M Scheers, Ann-Sofie Sandberg
Aug 3, 2005·Pflügers Archiv : European journal of physiology·Phillip S Oates, Carla Thomas
Aug 11, 2005·Pflügers Archiv : European journal of physiology·Bryan MackenzieMatthias A Hediger
Sep 15, 2005·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Gregory J AndersonAnn Smith
Sep 20, 2005·Current Gastroenterology Reports·Gregory J Anderson, David M Frazer
Sep 29, 2011·Biological Trace Element Research·Yan-Qin LiGui-Hua Zhuang
Dec 21, 2010·International Journal of Hematology·Clara Camaschella, Alessia Pagani
Mar 26, 2011·Genes & Nutrition·Michael D Garrick
Mar 2, 2005·Best Practice & Research. Clinical Haematology·Nancy C Andrews
Nov 13, 2003·European Journal of Pharmacology·Robert A ColvinDustin Thomas
Mar 17, 2004·Free Radical Biology & Medicine·Jennifer L TuriAndrew J Ghio
Dec 5, 2013·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Haiyan QiQidong Mao
Jul 20, 2002·Biochemical and Biophysical Research Communications·Desmond I BannonJoseph P Bressler
Dec 22, 1999·Biochemical Pharmacology·E C Theil
May 6, 2003·Gastroenterology·Antonello Pietrangelo
Dec 31, 1998·Gastroenterology·B R BaconJ H Hoofnagle
May 15, 2002·Life Sciences·Shoji Sakakibara, Yoritaka Aoyama
Apr 11, 2001·Mutation Research·J M De Freitas, R Meneghini
Oct 14, 2003·Toxicology and Applied Pharmacology·Wei ZhengJean-Francois Ghersi-Egea
Feb 24, 2001·Molecular Aspects of Medicine·P T LieuY Yang
Jun 22, 2001·Trends in Genetics : TIG·M F CellierE Richer
Sep 3, 1999·Neuroscience·J R BurdoJ R Connor
Jul 6, 2001·Toxicology Letters·J TallkvistB Lönnerdal
Dec 4, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·H TapieroK D Tew
Dec 4, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Haim Tapiero, Kenneth D Tew
Sep 18, 2001·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·P Brissot
Mar 15, 2002·The Journal of Nutritional Biochemistry·Nora R. Zerounian, Maria C. Linder
May 14, 1999·Trends in Biochemical Sciences·L C Kühn
Mar 30, 2002·Critical Reviews in Oncology/hematology·Juliana C Kwok, Des R Richardson
Apr 12, 2000·Microbes and Infection·J M BlackwellE N Miller
Jul 27, 2001·The International Journal of Biochemistry & Cell Biology·P AisenM Wessling-Resnick

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.