NRAS mutant melanoma: Towards better therapies.

Cancer Treatment Reviews
Tijana RandicStephanie Kreis

Abstract

Genetic alterations affecting RAS proteins are commonly found in human cancers. Roughly a fourth of melanoma patients carry activating NRAS mutations, rendering this malignancy particularly challenging to treat. Although the development of targeted as well as immunotherapies led to a substantial improvement in the overall survival of non-NRASmut melanoma patients (e.g. BRAFmut), patients with NRASmut melanomas have an overall poorer prognosis due to the high aggressiveness of RASmut tumors, lack of efficient targeted therapies or rapidly emerging resistance to existing treatments. Understanding how NRAS-driven melanomas develop therapy resistance by maintaining cell cycle progression and survival is crucial to develop more effective and specific treatments for this group of melanoma patients. In this review, we provide an updated summary of currently available therapeutic options for NRASmut melanoma patients with a focus on combined inhibition of MAPK signaling and CDK4/6-driven cell cycle progression and mechanisms of the inevitably developing resistance to these treatments. We conclude with an outlook on the most promising novel therapeutic approaches for melanoma patients with constitutively active NRAS. STATEMENT OF SIGNIF...Continue Reading

References

May 30, 1997·The Journal of Biological Chemistry·D B WhyteJ K Pai
Oct 6, 2000·Genes & Development·J W Harbour, D C Dean
Dec 3, 2002·Nature Reviews. Cancer·Marie Classon, Ed Harlow
Jan 19, 2006·Genes, Chromosomes & Cancer·Viswanathan MuthusamyMarcus W Bosenberg
Aug 15, 2006·Journal of Medical Genetics·Alisa M GoldsteinUNKNOWN Melanoma Genetics Consortium (GenoMEL)
Sep 13, 2008·Cell Stem Cell·Richard Mark White, Leonard I Zon
Feb 5, 2010·Pigment Cell & Melanoma Research·Zalfa A Abdel-MalekViki B Swope
Apr 12, 2011·Nature Structural & Molecular Biology·Amélie MarquetteNicolas Dumaz
Nov 10, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick A OberholzerLevi A Garraway
May 17, 2012·Cancer Research·Ian A PriorCarla Mattos
Jul 24, 2012·Cell·Eran HodisLynda Chin
Feb 2, 2013·The Journal of Investigative Dermatology·Alexander J LakhterSamisubbu R Naidu
Feb 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Christian PoschSusana Ortiz-Urda
Aug 16, 2013·Nature·Ludmil B AlexandrovMichael R Stratton
Aug 21, 2013·Cancer Research·Miguel F SeguraEva Hernando
Oct 4, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Karen E Sheppard, Grant A McArthur
Jan 11, 2014·Pigment Cell & Melanoma Research·David M Miller, Keith T Flaherty
Mar 5, 2014·Molecular Cancer·Jaykumar ThumarHarriet M Kluger
Aug 19, 2014·Pigment Cell & Melanoma Research·Vito W RebeccaKeiran S M Smalley
Aug 26, 2014·The Journal of Investigative Dermatology·Alan E SiroyMichael A Davies
Sep 24, 2014·The Surgical Clinics of North America·Amy A Mrazek, Celia Chao
Sep 26, 2014·Cancer Discovery·Christin E BurdNorman E Sharpless
Oct 18, 2014·Nature Reviews. Drug Discovery·Adrienne D CoxChanning J Der
Mar 3, 2015·Pigment Cell & Melanoma Research·Celia J VogelDaniel S Peeper
Mar 5, 2015·Cancer Immunology Research·Douglas B JohnsonJeffrey A Sosman
Mar 27, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mary E OlanichFrederic G Barr
May 29, 2015·The Journal of Investigative Dermatology·C PoschS Ortiz/Urda
Jun 20, 2015·Cell·UNKNOWN Cancer Genome Atlas Network
Sep 1, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R DummerUNKNOWN ESMO Guidelines Committee
Jan 6, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zhen TaoBo Lu
Jan 29, 2016·PloS One·Michael K KiesslingGerhard Rogler
Mar 30, 2016·Cancer Research·Maria Teresa Herrera-AbreuVioleta Serra
Apr 30, 2016·Nature Reviews. Cancer·A Hunter Shain, Boris C Bastian

❮ Previous
Next ❯

Citations

Sep 2, 2021·Biophysics Reviews·Ruth NussinovHyunbum Jang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Dermatology : International Journal for Clinical and Investigative Dermatology
Dorothee NashanStephan Grabbe
Clinical Advances in Hematology & Oncology : H&O
Philip Friedlander, F Stephen Hodi
© 2021 Meta ULC. All rights reserved