NREM parasomnias: a treatment approach based upon a retrospective case series of 512 patients

Sleep Medicine
Panagis DrakatosGuy D Leschziner

Abstract

Non-REM parasomnias are not uncommon conditions in the general population. Current treatment options are based on small case series and reports. In this study, we aimed to present the clinical experience from a large cohort of patients. Five hundred and twelve patients with Non-REM parasomnia or parasomnia overlap disorder (POD), who had undergone a video polysomnography and were exposed to treatment, were retrospectively identified. Treatment outcome was assessed based on patients' reports, and treatment approach on a locally accepted hierarchy of interventions. Forty percent of patients were diagnosed with sleepwalking, 23.8% with mixed-phenotype and 10% with POD. Ultimately, 97.2% reported adequate control of their symptoms. Moreover, 60.1% were treated with pharmacotherapy and 32.0% without, consistent across all phenotypes (p = 0.09). Benzodiazepines were the most common drugs prescribed (47.1%, p < 0.05). In the end, 37.7% of our patients were receiving a benzodiazepine as part of their successful treatment, 11.7% an antidepressant, 9.2% a z-drug, and 10.7% melatonin. Finally, 13.2%, 12.1%, and 5.8% of our patients reported good control of their symptoms with sleep hygiene, management of sleep-disordered breathing, and ps...Continue Reading

Citations

Aug 14, 2019·Current Opinion in Pulmonary Medicine·Panagis Drakatos, Guy Leschziner
Nov 26, 2019·Postgraduate Medicine·Maria NtafouliPanagiotis Bargiotas
Nov 20, 2019·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Milan NigamAlex Desautels
Mar 21, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Valentina GnoniIvana Rosenzweig
Sep 11, 2020·Journal of Sleep Research·Anna CastelnovoMaria Paola Canevini
Oct 9, 2018·Journal of Sleep Research·Panagis DrakatosBrian D Kent
Jun 12, 2020·Current Neurology and Neuroscience Reports·Margaret S Blattner, Gregory S Day
Nov 23, 2018·Clocks & Sleep·Maria HrozanovaRenata L Riha
Feb 3, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Muna IrfanMichael J Howell
Mar 4, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Jennifer M Mundt, Kelly G Baron
Jun 29, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Giuseppe LoddoFederica Provini
Jun 30, 2021·Sleep Medicine Reviews·Elena AntelmiGiuseppe Plazzi

❮ Previous
Next ❯

Methods Mentioned

BETA
cognitive behavioral therapy
pharmacotherapy
pharmacotherapies

Software Mentioned

SPSS Statistics

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Continuum : Lifelong Learning in Neurology
Muna IrfanMichael J Howell
Journal of Child and Adolescent Psychopharmacology
Louis T van ZylC M Shapiro
Neurologic Clinics
Raman K Malhotra, Alon Y Avidan
© 2022 Meta ULC. All rights reserved