NRF-1 genotypes and endurance exercise capacity in young Chinese men

British Journal of Sports Medicine
Z HeAlejandro Lucia

Abstract

Nuclear respiratory factor 1 (NRF-1) is a critical component of the energy-sensing mechanism in mammalian cells, and translates physiological signals (particularly those induced by exercise) into increased capacity for mitochondrial biogenesis and oxidative phosphorylation. To study the possible association between rs2402970, rs6949152 and rs10500120 NRF-1 genotypes and several phenotypes indicative of maximum (VO(2max)) and submaximum aerobic capacity (ventilatory threshold (VT) and metabolic cost of submaximum running at 12 km/hour (running economy; RE)) both at baseline and in response to a 18-week endurance training programme in young Chinese men of Han origin (n = 102; 19 (SD 1) years). For rs2402970, a significant genotype effect was seen for VT (p = 0.004) and RE (p = 0.027). For rs6949152, a significant interaction (genotypextraining) effect (p = 0.047) was found for VT. There is an association between NRF-1 genotypes (rs2402970 and rs6949152 polymorphisms) and the baseline and/or training response of human aerobic capacity. More research is needed to corroborate our data in other ethnic groups with lower fitness levels at the pre-training state (particularly Caucasians) and to identify the molecular mechanisms involved...Continue Reading

Citations

Jan 29, 2010·European Journal of Applied Physiology·Zi-Hong HeAlejandro Lucia
Nov 29, 2012·Rejuvenation Research·Catalina SantiagoAlejandro Lucia
Jul 28, 2009·Annual Review of Genomics and Human Genetics·Elaine A OstranderGary K Ostrander
Dec 1, 2010·The Veterinary Journal·Wiebke SchröderOttmar Distl
Nov 17, 2017·BMC Genomics·Camilla J WilliamsJeff S Coombes
May 8, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·James P RaleighBrendon J Gurd
Jan 4, 2020·Molecular Genetics and Genomics : MGG·N R HarveyL R Griffiths
Jul 22, 2020·International Journal of Sports Medicine·Javier Alvarez-RomeroDanielle Hiam
May 1, 2021·Genes·Juan Del Coso, Alejandro Lucia
May 21, 2011·Molecular Neurodegeneration·Elahe Taherzadeh-FardLarissa Arning

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