Nrf2 activator, sulforaphane ameliorates autism-like symptoms through suppression of Th17 related signaling and rectification of oxidant-antioxidant imbalance in periphery and brain of BTBR T+tf/J mice.

Behavioural Brain Research
Ahmed NadeemMohammed Alqinyah

Abstract

Autism is a neurodevelopmental disease which is characterized by its core behavioral symptoms such as impairment in social interaction and stereotyped repetitive behavior. Th17 immune responses and oxidative stress are reported to be elevated in both human autistic subjects and BTBR T + Itpr3tf/J (BTBR) mice. On the other hand, activation of nuclear factor erythroid 2 related factor (Nrf2), a master transcription factor is essential for the management of anti-inflammatory and antioxidant genes. Sulforaphane activates Nrf2 and thus is considered a potential approach to treat several neurological disorders including autism. In the current work, we used sulforaphane in asocial BTBR mice and its social counterpart C57/BL6 (C57) mice to assess its therapeutic potential and molecular mechanisms (Th17 immune responses, and oxidant-antioxidant balance) through which it acts. Our results demonstrate that BTBR treated with sulforaphane had reduced self-grooming/marble burying behavior, and increased social interaction in three chambered sociability test as compared to untreated BTBR mice. Further, sulforaphane-treated BTBR mice had reduced Th17 immune responses (STAT3, RORC, IL-17 A and IL-23R expression in CD4 + T cells), oxidative stre...Continue Reading

Citations

Oct 14, 2020·Nature Immunology·Takafumi SuzukiMasayuki Yamamoto
Jan 26, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Geir BjørklundSalvatore Chirumbolo
Mar 13, 2021·Pharmacology Research & Perspectives·Hao LiuMei-Xian Ou
Nov 27, 2020·Redox Biology·Kishore Kumar S NarasimhanNamakkal S Rajasekaran
Jul 26, 2021·Behavioural Brain Research·Vasiliy V ReshetnikovNatalya P Bondar
Aug 3, 2021·Metabolic Brain Disease·Narueporn LikhitweerawongSiriporn C Chattipakorn

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