Nrf2 and NF-κB modulation by Plumbagin attenuates functional, behavioural and biochemical deficits in rat model of neuropathic pain

Pharmacological Reports : PR
Vijay ArruriAshutosh Kumar

Abstract

Plumbagin is known to exhibit a broad range of biological activities including anti-cancer, antimicrobial and has been widely used traditionally. Nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB) inhibitory and Nuclear factor (erythroid derived-2) like-2 (Nrf2) modulatory activities of Plumbagin have been reported already. In nerve injury model of neuropathy in rats, the role of NF-κB upregulation and declined antioxidant defence has been well recognized. So, we evaluated neuroprotective potential of Plumbagin in chronic constriction injury (CCI) of sciatic nerve induced neuropathic pain in male Sprague-Dawley rats. Animals were tested for functional, behavioural and biochemical changes. Various markers associated with oxidative stress and inflammatory changes were assessed in the sciatic nerve and dorsal root ganglion (DRG) of the animals exposed to CCI mediated nerve injury. CCI induced nerve injury led to long-lasting mechanical hyperalgesia, loss of hind limb function and abnormal pain sensation. Plumbagin treatment (10 and 20mg/kg, po) significantly and dose-dependently reversed mechanical hyperalgesia and other functional deficits. There was a marked increase in NF-κB and reduced Nrf2 levels in sciati...Continue Reading

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Citations

Sep 15, 2020·Journal of Receptor and Signal Transduction Research·Jiajia LiYinghui Wu
Mar 24, 2018·Inflammopharmacology·Amit Chand GuptaDnyaneshwar U Bawankule
Mar 27, 2021·Molecular Biology Reports·Vijay Kumar ArruriShashi Bala Singh
Aug 27, 2021·Experimental and Therapeutic Medicine·Wenyan ShanJitong Liu

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