Nrf2 in aging - Focus on the cardiovascular system

Vascular Pharmacology
Damian KloskaAnna Grochot-Przeczek

Abstract

Aging is the most critical risk factor for the development of cardiovascular diseases and their complications. Therefore, the fine-tuning of cellular response to getting older is an essential target for prospective therapies in cardiovascular medicine. One of the most promising targets might be the transcription factor Nrf2, which drives the expression of cytoprotective and antioxidative genes. Importantly, Nrf2 expression correlates with potential lifespan in rodents. However, the effect of Nrf2 activity in vascular diseases might be ambiguous and strongly depend on the cell type. On the one hand, the Nrf2 activity may protect cells from oxidative stress and senescence, on the other hand, total lack of Nrf2 is protective against atherosclerosis development. Therefore, this review aims to discuss the current knowledge on the role played by the transcription factor Nrf2 in cardiovascular diseases and its potential effects on aging.

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Citations

Jun 19, 2019·Current Pharmaceutical Design·Allison B ReissJoshua De Leon
Jul 4, 2020·Oxidative Medicine and Cellular Longevity·Aleksandra KopaczAleksandra Piechota-Polanczyk
Dec 24, 2018·Aging and Disease·Ashok K ShettyLeelavathi N Madhu
Sep 13, 2020·Molecular and Cellular Biochemistry·Huan YuanJian-Hui Xiao
Feb 26, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Samsul ArefinPeter Stenvinkel
Apr 3, 2020·Free Radical Biology & Medicine·Aleksandra KopaczAnna Grochot-Przeczek
Sep 7, 2020·Mechanisms of Ageing and Development·Ioanna Daskalaki, Nektarios Tavernarakis
Apr 2, 2021·Circulation Research·Stephanie M CicaleseRita C Tostes
Apr 23, 2021·Journal of Physiology and Biochemistry·Jiaru LiuXiuru Guan

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