NRF2 Is a Key Target for Prevention of Noise-Induced Hearing Loss by Reducing Oxidative Damage of Cochlea

Scientific Reports
Yohei HonkuraHozumi Motohashi

Abstract

Noise-induced hearing loss (NIHL) is one of the most common sensorineural hearing deficits. Recent studies have demonstrated that the pathogenesis of NIHL is closely related to ischemia-reperfusion injury of cochlea, which is caused by blood flow decrease and free radical production due to excessive noise. This suggests that protecting the cochlea from oxidative stress is an effective therapeutic approach for NIHL. NRF2 is a transcriptional activator playing an essential role in the defense mechanism against oxidative stress. To clarify the contribution of NRF2 to cochlear protection, we examined Nrf2(-/-) mice for susceptibility to NIHL. Threshold shifts of the auditory brainstem response at 7 days post-exposure were significantly larger in Nrf2(-/-) mice than wild-type mice. Treatment with CDDO-Im, a potent NRF2-activating drug, before but not after the noise exposure preserved the integrity of hair cells and improved post-exposure hearing levels in wild-type mice, but not in Nrf2(-/-) mice. Therefore, NRF2 activation is effective for NIHL prevention. Consistently, a human NRF2 SNP was significantly associated with impaired sensorineural hearing levels in a cohort subjected to occupational noise exposure. Thus, high NRF2 acti...Continue Reading

References

Jan 1, 1979·Acta Oto-laryngologica·M C Liberman, D G Beil
Jan 1, 1991·Acta Oto-laryngologica·H YamaneH Iguchi
Dec 26, 2001·American Journal of Respiratory Cell and Molecular Biology·Hye-Youn ChoSteven R Kleeberger
Jun 18, 2003·Audiology & Neuro-otology·Josef M MillerJochen Schacht
Sep 11, 2004·Biochemical and Biophysical Research Communications·Tae YamamotoMasayuki Yamamoto
Nov 3, 2004·Trends in Molecular Medicine·Hozumi Motohashi, Masayuki Yamamoto
Jan 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·T SatohS A Lipton
Feb 17, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sharon G Kujawa, M Charles Liberman
Sep 19, 2006·Chemical Research in Toxicology·Toyo SakuraiKoji Uchida
Dec 5, 2006·Hearing Research·Colleen G Le PrellJosef M Miller
Mar 27, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jacqui M MarzecSteven R Kleeberger
Jul 1, 2008·Archives of Biochemistry and Biophysics·Atsushi MaruyamaKen Itoh
Apr 27, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Zoltan UngvariAnna Csiszar
Mar 10, 2011·Nitric Oxide : Biology and Chemistry·Akira Uruno, Hozumi Motohashi
Jul 21, 2011·World Journal of Cardiology·Maria-Giulia PerrelliClaudia Penna
Oct 25, 2011·Biochemical and Biophysical Research Communications·Tomofumi HoshinoAkira Hara
Nov 30, 2011·Noise & Health·Amir H MehrparvarZiba Loukzadeh
Mar 1, 2012·Neuroscience·J S ParkS M Park
Mar 13, 2012·Cell Metabolism·Houman AshrafianHugh Watkins
Feb 21, 2013·Hearing Research·Tatsuya YamasobaKenji Kondo
Mar 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anna Rita FetoniDiana Troiani
Apr 11, 2013·Molecular and Cellular Biology·Takafumi SuzukiMasayuki Yamamoto
Jan 21, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Keiichi ShirasakiMasayuki Yamamoto
May 29, 2014·Cancer Prevention Research·Keiichiro HiramotoMasayuki Yamamoto
Feb 24, 2015·Experimental & Molecular Medicine·Se-Jin KimRaekil Park

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Citations

Jun 10, 2015·Biochemical and Biophysical Research Communications·Sun Ju KimSangkyu Lee
Mar 18, 2017·Frontiers in Neuroscience·Annick GillesErik Fransen
Feb 17, 2018·Cancer Science·Hiroshi Kitamura, Hozumi Motohashi
May 3, 2018·Physiological Reviews·Masayuki YamamotoHozumi Motohashi
Dec 23, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Min Soo KimKyung Song
Apr 21, 2018·Journal of Neurochemistry·Shigefumi MoriokaTakehiko Ueyama
Jul 5, 2017·Molecular and Cellular Biology·Shohei MurakamiHozumi Motohashi
Mar 13, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Adrien A EshraghiRahul Mittal
Apr 1, 2019·Cancer Medicine·Shijia WuYongheng Bai
Mar 21, 2019·Current Drug Targets·Azam HosseinzadehSaeed Mehrzadi
Sep 10, 2019·British Journal of Hospital Medicine·Tonghui DingKe Liu
Feb 10, 2018·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Anna R FetoniGaetano Paludetti
Feb 29, 2020·Antioxidants·Emiliano PanieriLuciano Saso
Dec 4, 2019·Archives of Pharmacal Research·Akihito Otsuki, Masayuki Yamamoto
Apr 26, 2020·International Journal of Molecular Sciences·Masahiro Nezu, Norio Suzuki
Jun 1, 2017·Antioxidants & Redox Signaling·Verónica MiguelSantiago Lamas
Dec 5, 2019·The Journal of the Acoustical Society of America·Sarah N GittlemanTanisha L Hammill
Apr 8, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Seyit Mehmet CeylanMustafa Emre Gulbagci
Mar 2, 2019·Future Science OA·Pieranna ChiarellaArio de Marco
Oct 18, 2020·Environmental Science and Pollution Research International·Long MiaoYuepu Pu
Sep 13, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Yun Yeong LeeYun-Hoon Choung
Dec 16, 2020·Npj Aging and Mechanisms of Disease·Tetsuya OishiHozumi Motohashi
Apr 1, 2021·Experimental Gerontology·Hideaki OikeKayo Azami
Apr 30, 2021·Frontiers in Pharmacology·Dafei LiGuangyong Tian

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Agilent G2201AA Chem - Station
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