Nrf2-mediated mucoprotective and anti-inflammatory actions of Artemisia extracts led to attenuate stress related mucosal damages

Journal of Clinical Biochemistry and Nutrition
Jong-Min ParkKi-Baik Hahm

Abstract

The aim of this study was to compare biological actions between isopropanol and ethanol extracts of Artemisia including antioxidant, anti-inflammatory, and cytoprotective actions. Antioxidant activities were evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) method and confocal microscopy on lipopolysaccharide-induced RGM1 cells, cytoprotection effects evaluated by detecting heme oxygenase-1 (HO-1), Nf-E2 related factor2 (Nrf2) and heat shock protein 70 (HSP70), and anti-inflammatory effects investigated by measuring inflammatory mediators. Water immersion restraint stress was imposed to provoke stress related mucosal damages (SRMD) in rats. Isopropanol extracts of Artemisia showed the higher DPPH radical scavenging activity and lesser LPS-induced reactive oxygen species productions and increased HO-1 expression through increased nuclear translocation of Nrf2 transcription factor compared to ethanol extracts. The increased expression of HSP70 and decreased expression of endothelin-1 were only increased with isopropanol extracts. A concentration-dependent inhibition of LPS-induced COX-2 and iNOS even at a rather lower concentration than ethanol extract was achieved with isopropanol extracts. Cytokine protein array revealed Art...Continue Reading

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Citations

Jan 18, 2018·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Joo-Il KimKyung-Tae Lee
Jan 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kem Ok KimKi Sung Kang
May 19, 2019·Molecular Biology Reports·Younghwan HanJaeku Kang
Aug 18, 2020·Journal of Clinical Biochemistry and Nutrition·Jeong Min AnKi Baik Hahm

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Methods Mentioned

BETA
nuclear translocation
Antibody Array
transfection

Software Mentioned

Gelpro32

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